dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; palladium diacetate; caesium carbonate in 1,4-dioxane; water T=80°C; Suzuki Coupling; 3 h; Inert atmosphere;

1.1: caesium carbonate; tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran; water / 2 h / 70 °C / |Inert atmosphere 2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C / |Inert atmosphere 2.2: 4 h / 0 °C / |Inert atmosphere 3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C / |Inert atmosphere 4.1: Grubb's 2nd generation catalyst / dichloromethane / 4 h / 40 °C / |Inert atmosphere 5.1: acetyl chloride / methanol / 10 h / |Inert atmosphere View Scheme