4-(4-硝基-苄基氨基)-哌啶-1-羧酸叔丁酯合成路线 （共 2 条）
反应条件
1: With triethylamine in methanol
21 h; Heating / reflux;
2: With sodium tetrahydroborate in methanol
T=20°C; 6 h;
3: With sodium hydrogencarbonate in methanol; water
参考文献
ACTELION PHARMACEUTICALS LTD.
Patent: US2008/76762 A1, 2008 ;
Location in patent: Page/Page column 38-39; 54-55 ;
US 20080076762 A1
反应条件
1: With titanium(IV) isopropylate in ethanol
T=0 - 20°C;
2: With sodium tetrahydroborate; acetic acid in ethanol
T=20°C; 3 h;
参考文献
VITAS PHARMA RESEARCH PVT LTD; ALAPATI, Chandrasekhar; BANERJEE, Ankita; RANGARAJAN, Radha; KUMAR, Rajinder
Patent: WO2014/57415 A2, 2014 ;
Location in patent: Page/Page column 25 ;
