3-(4-氰基吡啶-2-硫代)苯甲酸合成路线 (共 1 条)
反应条件
1: meta-mercaptobenzoic acid With sodium hydride in N,N-dimethyl-formamide
T=0°C; 0.166667 h;
2: 2-Chloro-isonicotinonitrile in N,N-dimethyl-formamide
T=20°C; 18 h;
3: With hydrogenchloride in water; N,N-dimethyl-formamide
参考文献
ELI LILLY AND COMPANY
Patent: WO2006/57860 A1, 2006 ;
Location in patent: Page/Page column 73 ;
WO 2006/057860 A1