1-苄基-1,2,5,6-四氢吡啶-3-羧酸甲酯合成路线 （共 9 条）
反应条件
sodium hydrogencarbonate in ethanol
T=0 - 110°C; 5.08333 h;
参考文献
Long, Sha; Stefani, Francesca Romana; Biondi, Stefano; Ghiselli, Giancarlo; Panunzio, Mauro
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 18 p. 5811 - 5822
反应条件
1: in toluene
T=20°C;
2: With sodium tetrahydroborate in methanol
参考文献
Han, Min Tong; Martin, Marie-Therese; Chiaroni, Angele; Benechie, Michel; Marazano, Christian
Organic Letters, 2005 , vol. 7, # 12 p. 2437 - 2440
反应条件
methanesulfonyl chloride; triethylamine in dichloromethane
T=0 - 20°C;
参考文献
Chavan, Subhash P.; Khobragade, Dushant A.; Pathak, Ashok B.; Kalkote, Uttam R.
Synthetic Communications, 2007 , vol. 37, # 18 p. 3143 - 3149
反应条件
1: NaBH4 / methanol / 2 h / 0 - 20 °C
2: triethylamine; MeSO2Cl / CH2Cl2 / 0 - 20 °C
View Scheme
参考文献
Chavan, Subhash P.; Khobragade, Dushant A.; Pathak, Ashok B.; Kalkote, Uttam R.
Synthetic Communications, 2007 , vol. 37, # 18 p. 3143 - 3149
反应条件
1: 82 percent / NaH / benzene / 3 h / Heating
2: NaBH4 / methanol / 2 h / 0 - 20 °C
3: triethylamine; MeSO2Cl / CH2Cl2 / 0 - 20 °C
View Scheme
参考文献
Chavan, Subhash P.; Khobragade, Dushant A.; Pathak, Ashok B.; Kalkote, Uttam R.
Synthetic Communications, 2007 , vol. 37, # 18 p. 3143 - 3149
反应条件
1: 90 percent / triethylamine / Heating
2: 82 percent / NaH / benzene / 3 h / Heating
3: NaBH4 / methanol / 2 h / 0 - 20 °C
4: triethylamine; MeSO2Cl / CH2Cl2 / 0 - 20 °C
View Scheme
参考文献
Chavan, Subhash P.; Khobragade, Dushant A.; Pathak, Ashok B.; Kalkote, Uttam R.
Synthetic Communications, 2007 , vol. 37, # 18 p. 3143 - 3149
反应条件
1: sodium carbonate / water / pH 13 - 14
2: 1,2-dichloro-ethane; 1-chloroethyl chlorocarbonate / dichloromethane / 6.25 h / 0 - 100 °C / pH 13 - 14
3: sodium hydrogencarbonate / ethanol / 5.08 h / 0 - 110 °C
View Scheme
参考文献
Long, Sha; Stefani, Francesca Romana; Biondi, Stefano; Ghiselli, Giancarlo; Panunzio, Mauro
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 18 p. 5811 - 5822
反应条件
1: 1,2-dichloro-ethane; 1-chloroethyl chlorocarbonate / dichloromethane / 6.25 h / 0 - 100 °C / pH 13 - 14
2: sodium hydrogencarbonate / ethanol / 5.08 h / 0 - 110 °C
View Scheme
参考文献
Long, Sha; Stefani, Francesca Romana; Biondi, Stefano; Ghiselli, Giancarlo; Panunzio, Mauro
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 18 p. 5811 - 5822
反应条件
sodium hydroxide; sodium tetrahydroborate in methanol; water
T=0°C; 0.25 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Paglietti, Giuseppe; Sanna, Paolo; Nuvole, Antonio; Soccolini, Francesco; Acheson, R. Morrin
Journal of Chemical Research, Miniprint, 1983 , # 10 p. 2326 - 2342
