1: 1) n-Butyllithium / 1) THF, ice bath , 6 h, 2) THF, room temperature, 4 h 2: 85 percent / acetonitrile / 12 h / Heating 3: 1) NaBH4, 2) 2N-HCl / 1) ethanol, 0-5 deg C, 2 h, 2) methanol, heating, 30 min View Scheme

1: 85 percent / acetonitrile / 12 h / Heating 2: 1) NaBH4, 2) 2N-HCl / 1) ethanol, 0-5 deg C, 2 h, 2) methanol, heating, 30 min View Scheme

1: 89 percent / 16 h / Heating 2: 1) n-Butyllithium / 1) THF, ice bath , 6 h, 2) THF, room temperature, 4 h 3: 85 percent / acetonitrile / 12 h / Heating 4: 1) NaBH4, 2) 2N-HCl / 1) ethanol, 0-5 deg C, 2 h, 2) methanol, heating, 30 min View Scheme

1: 4-methoxy-benzaldehyde With n-butyllithium; MeNH(CH2)NMe2 in tetrahydrofuran; hexane T=-20°C; 24.25 h; Inert atmosphere; 2: chloro-trimethyl-silane in tetrahydrofuran; hexane T=-40 - 23°C; 1 h; Inert atmosphere;

hydrogenchloride; sodium tetrahydroborate 1) ethanol, 0-5 deg C, 2 h, 2) methanol, heating, 30 min; Yield given. Multistep reaction;

n-butyllithium 1) THF, a) -78 deg C, b) room temperature, 1.5 h, 2) THF, a) -78 deg C, 0.5 h, b) room temperature, 16 h; Yield given. Multistep reaction;