1: tert-butyl alcohol With sodium hydride in isobutyramide T=20°C; 2.25 h; 2: 1-bromo-3,5-difluoro-benzene T=20°C; 0.5 h;

1: With tris-(dibenzylideneacetone)dipalladium(0); benzophenone; sodium methylate; 2,2'-bis-(diphenylphosphino)-1,1'- binaphthyl in toluene T=80°C; 40 h; 2: With hydroxylamine hydrochloride; sodium acetate in methanol T=20°C; 2.5 h; 3: With sodium hydroxide in methanol; water