N-[4-(1H-咪唑-1-基)丁基]-2-异丙基-11-氧代-11H-吡啶并[2,1-b]喹唑啉-8-甲酰胺合成路线 （共 8 条）
反应条件
bis-triphenylphosphine-palladium(II) chloride; tributyl-amine; triphenylphosphine in water; N,N-dimethyl-formamide
T=100°C; P=10343 Torr; 12 h;
参考文献
Tilley, Jefferson W.; Coffen, David L.; Schaer, Beatrice H.; Lind, Joan
Journal of Organic Chemistry, 1987 , vol. 52, # 12 p. 2469 - 2474
反应条件
in N,N-dimethyl-formamide
T=35°C; 18 h;
参考文献
Tilley, Jefferson W.; Levitan, Paul; Lind, Joan; Welton, Ann F.; Crowley, Herman J.; et al.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 1 p. 185 - 193
反应条件
1: 74 percent / Et3N, H2 / Raney cobalt / methanol / 3 h / 100 - 110 °C / 62057.8 Torr
2: 87 percent / dimethylformamide / 18 h / 35 °C
View Scheme
参考文献
Tilley, Jefferson W.; Levitan, Paul; Lind, Joan; Welton, Ann F.; Crowley, Herman J.; et al.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 1 p. 185 - 193
反应条件
1: 84 percent / K2CO3 / dimethylformamide / 24 h / Ambient temperature
2: 87 percent / dimethylformamide / 18 h / 35 °C
View Scheme
参考文献
Tilley, Jefferson W.; Levitan, Paul; Lind, Joan; Welton, Ann F.; Crowley, Herman J.; et al.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 1 p. 185 - 193
反应条件
1: acetonitrile / 1 h / 60 °C
2: 89.9 percent / 2-methoxy-ethanol / 10 h / Heating
3: 73 percent / bromine / acetic acid / 1 h / 15 °C
4: 99.8 percent / bis(triphenylphosphine)palladium dichloride, triphenylphosphine, tributylamine / dimethylformamide; H2O / 12 h / 100 °C / 10343 Torr
View Scheme
参考文献
Tilley, Jefferson W.; Coffen, David L.; Schaer, Beatrice H.; Lind, Joan
Journal of Organic Chemistry, 1987 , vol. 52, # 12 p. 2469 - 2474
反应条件
1: thionyl chloride / 3.5 h / Heating
2: acetonitrile / 1 h / 60 °C
3: 89.9 percent / 2-methoxy-ethanol / 10 h / Heating
4: 73 percent / bromine / acetic acid / 1 h / 15 °C
5: 99.8 percent / bis(triphenylphosphine)palladium dichloride, triphenylphosphine, tributylamine / dimethylformamide; H2O / 12 h / 100 °C / 10343 Torr
View Scheme
参考文献
Tilley, Jefferson W.; Coffen, David L.; Schaer, Beatrice H.; Lind, Joan
Journal of Organic Chemistry, 1987 , vol. 52, # 12 p. 2469 - 2474
反应条件
1: 73 percent / bromine / acetic acid / 1 h / 15 °C
2: 99.8 percent / bis(triphenylphosphine)palladium dichloride, triphenylphosphine, tributylamine / dimethylformamide; H2O / 12 h / 100 °C / 10343 Torr
View Scheme
参考文献
Tilley, Jefferson W.; Coffen, David L.; Schaer, Beatrice H.; Lind, Joan
Journal of Organic Chemistry, 1987 , vol. 52, # 12 p. 2469 - 2474
反应条件
1: acetonitrile / 1 h / 60 °C
2: 89.9 percent / 2-methoxy-ethanol / 10 h / Heating
3: 73 percent / bromine / acetic acid / 1 h / 15 °C
4: 99.8 percent / bis(triphenylphosphine)palladium dichloride, triphenylphosphine, tributylamine / dimethylformamide; H2O / 12 h / 100 °C / 10343 Torr
View Scheme
参考文献
Tilley, Jefferson W.; Coffen, David L.; Schaer, Beatrice H.; Lind, Joan
Journal of Organic Chemistry, 1987 , vol. 52, # 12 p. 2469 - 2474
