Boc-1-氨基环丙基甲酸合成路线 （共 20 条）
反应条件
lithium hydroxide in tetrahydrofuran; methanol; water T=0 - 20°C; 20 h;
参考文献
Brackmann, Farina; Es-Sayed, Mazen; De Meijere, Armin
European Journal of Organic Chemistry, 2005 , # 11 p. 2250 - 2258
反应条件
1: 100 percent / toluene / 90 °C 2: 96 percent / NaOH/MeOH / 25 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 24, # 36 p. 3839 - 3840
反应条件
1: 89 percent / diethyl ether / -15 °C 2: 100 percent / toluene / 90 °C 3: 96 percent / NaOH/MeOH / 25 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 24, # 36 p. 3839 - 3840
反应条件
ruthenium trichloride; sodium periodate
参考文献
Tetrahedron Letters, , vol. 34, # 26 p. 4193 - 4196
反应条件
1: EDC; NMM; DMAP 2: DIBAL / hexane; tetrahydrofuran / -78 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 11, # 12 p. 2551 - 2568
反应条件
1: With 4-methyl-morpholine; isobutyl chloroformate in ethylene glycol dimethyl ether T=-70 - -5°C; 2: With sodium tetrahydroborate in ethylene glycol dimethyl ether T=-15 - 20°C; 3: With water in ethylene glycol dimethyl ether
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH
Patent: US2011/28441 A1, 2011 ;
Location in patent: Page/Page column 14 ;
US 20110028441 A1
反应条件
4-methyl-morpholine; sodium borohydride in ethylene glycol dimethyl ether; water
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH
Patent: US2012/35143 A1, 2012 ;
反应条件
water 12 h; Heating;
参考文献
Wheeler, Thomas N.; Ray, John A.
Synthetic Communications, 1988 , vol. 18, # 2 p. 141 - 150
反应条件
in ethanol
T=0°C; 7 h; undivided electrolytic cell with Pt-electrodes; current i = 9 mAcm-2;
参考文献
Kienzler, Thomas; Strazewski, Peter; Tamm, Christoph
Helvetica Chimica Acta, 1992 , vol. 75, # 4 p. 1078 - 1084
