6-氯-2-(4-氯苯基)咪唑并[1,2-a]吡啶合成路线 （共 6 条）
反应条件
in N,N-dimethyl-formamide T=150°C; 19 h;
参考文献
Cooper, Laura C.; Chicchi, Gary G.; Dinnell, Kevin; Elliott, Jason M.; Hollingworth, Gregory J.; Kurtz, Marc M.; Locker, Karen L.; Morrison, Denise; Shaw, Duncan E.; Tsao, Kwei-Lan; Watt, Alan P.; Williams, Angela R.; Swain, Christopher J.
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 9 p. 1233 - 1236
反应条件
1: para-chloroacetophenone With [Bmim]Br3 in neat (no solvent) T=30°C; 0.0833333 h; 2: 5-Chloro-pyridin-2-ylamine With sodium carbonate in neat (no solvent) T=30°C; 0.666667 h;
参考文献
Le, Zhang-Gao; Xie, Zong-Bo; Xu, Jian-Ping
Molecules, 2012 , vol. 17, # 11 p. 13368 - 13375
反应条件
acetic acid in water T=50 - 55°C; 4 h;
参考文献
Lange; Karolak-Wojciechowska; Wejroch; Rump
Acta Poloniae Pharmaceutica - Drug Research, 2001 , vol. 58, # 1 p. 43 - 52
反应条件
1.1: 77 percent / acetic acid / H2O / 4 h / 50 - 55 °C 2.1: MeI / CH2Cl2 / 24 h / 20 °C 2.2: H2O / 4 h / Heating View Scheme
参考文献
Lange; Karolak-Wojciechowska; Wejroch; Rump
Acta Poloniae Pharmaceutica - Drug Research, 2001 , vol. 58, # 1 p. 43 - 52
反应条件
1.1: 77 percent / acetic acid / H2O / 4 h / 50 - 55 °C 2.1: MeI / CH2Cl2 / 24 h / 20 °C 2.2: H2O / 4 h / Heating 3.1: 85 percent / aq. KOH / ethanol / 8 h / Heating View Scheme
参考文献
Lange; Karolak-Wojciechowska; Wejroch; Rump
Acta Poloniae Pharmaceutica - Drug Research, 2001 , vol. 58, # 1 p. 43 - 52
反应条件
1: in N,N-dimethyl-formamide T=75°C; Vilsmeier formylation; 16 h; 2: With sodium hydroxide
参考文献
Cooper, Laura C.; Chicchi, Gary G.; Dinnell, Kevin; Elliott, Jason M.; Hollingworth, Gregory J.; Kurtz, Marc M.; Locker, Karen L.; Morrison, Denise; Shaw, Duncan E.; Tsao, Kwei-Lan; Watt, Alan P.; Williams, Angela R.; Swain, Christopher J.
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 9 p. 1233 - 1236
