5-溴-2-氯吡啶 N-氧化物合成路线 (共 3 条)
反应条件
1: With urea hydrogen peroxide addition compound; trifluoroacetic anhydride in chloroform T=0 - 20°C; 1 h; 2: With sodium thiosulfate in chloroform; water T=20°C; 0.666667 h;
参考文献
BANYU PHARMACEUTICAL CO., LTD.
Patent: WO2006/59778 A1, 2006 ;
Location in patent: Page/Page column 57 ;
WO 2006/059778 A1
反应条件
trifluoroacetic anhydride in chloroform; ethyl acetate
参考文献
BANYU PHARMACEUTICAL CO., LTD.
Patent: EP1820797 A1, 2007 ;
反应条件
triethylamine in acetonitrile T=100°C;
参考文献
WO2009/111337 A1, ;
Page/Page column 178-179 ;
WO 2009/111337 A1