4-碘-1-甲基-2(1H)-吡啶酮合成路线 （共 3 条）
反应条件
potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct; 1,1'-bis(diphenylphosphino)ferrocene in 1,4-dioxane T=120°C; 5 h; Inert atmosphere;
参考文献
INCYTE CORPORATION; ZHANG, Colin; QIAN, Ding-quan; ZHUO, Jincong; YAO, Wenqing
Patent: WO2010/75270 A1, 2010 ;
Location in patent: Page/Page column 89-90 ;
WO 2010/075270 A1
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=20°C;
参考文献
Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH
Patent: US2010/331320 A1, 2010 ;
Location in patent: Page/Page column 70; 71 ;
反应条件
1: 4-iodopyridin-2-ol With sodium hydride in N,N-dimethyl-formamide; mineral oil
T=0°C;
2: methyl iodide in N,N-dimethyl-formamide; mineral oil
T=20°C; 2 h;
参考文献
INCYTE CORPORATION; ZHANG, Colin; QIAN, Ding-quan; ZHUO, Jincong; YAO, Wenqing
Patent: WO2010/75270 A1, 2010 ;
Location in patent: Page/Page column 87 ;
WO 2010/075270 A1
