反应条件
1: thionyl chloride / 0 - 80 °C 2: 4-(N,N-dimethlyamino)pyridine; triethylamine / tetrahydrofuran / 15 h 3: methanol; lithium borohydride / tetrahydrofuran; diethyl ether / 2 h 4: Dess-Martin periodane / dichloromethane / 0.5 h View Scheme
参考文献
AMGEN INC.; ASHTON, Kate; BARTBERGER, Michael D.; BOURBEAU, Matthew Paul; CROGHAN, Michael D.; FOTSCH, Christopher H.; HUNGATE, Randall W.; KONG, Ke; NISHIMURA, Nobuko; NORMAN, Mark H.; PENNINGTON, Lewis D.; REICHELT, Andreas; SIEGMUND, Aaron C.; TADESSE, Seifu; ST. JEAN, David Jr; YANG, Kevin C.; YAO, Guomin
Patent: WO2013/173382 A1, 2013 ;