美沙啦嗪(5-氨基水杨酸)合成路线 （共 91 条）
反应条件
1: With potassium hydroxide T=220°C; P=37503.8 Torr; 1 h; 2: With hydrogenchloride; water T=80°C; pH=4; Reagent/catalystTemperaturePressureTime;
参考文献
Zhejiang Huahai Pharmaceutical Co., Ltd.; Huazhong University of Science and Technology; Li, Guangxing; Li, Jinjin; Zhu, Dajian; Jiang, Qiang; Cai, Lingli; Xie, Yong; Gan, Lixin
Patent: US2013/281730 A1, 2013 ;
Location in patent: Paragraph 0050 ;
反应条件
1: T=95 - 98°C; pH=2; 2: With sodium hydroxide T=85 - 95°C; pH=11.5 - 12; 2.5 h; Product distribution / selectivity;
参考文献
NEWREKA CHEMICALS PRIVATE LIMITED
Patent: US2012/203031 A1, 2012 ;
Location in patent: Page/Page column 14-16 ;
反应条件
1: 4-amino-phenol With sodium hydroxide T=130 - 150°C; Kolbe-Schmitt reaction; 2: carbon dioxide Kolbe-Schmitt reaction; P=67506.8 Torr; AutoclaveHeating; 3: With sulfuric acid Kolbe-Schmitt reaction; pH=2 - 3;
参考文献
Lue, Hailiang; Liu, Junqi; Xing, Cunzhang; Tan, Mingchen; Gao, Fei
Asian Journal of Chemistry, 2011 , vol. 23, # 9 p. 3819 - 3823
反应条件
sulfuric acid; zinc T=50 - 80°C;
参考文献
Gazzetta Chimica Italiana, , vol. 36 II, p. 89
Gazzetta Chimica Italiana, , vol. 59, p. 14
反应条件
2,3-dihydroxybenzoate decarboxylase from Aspergillus oryzae in aq. phosphate buffer T=30°C; Kolbe-Schmidt Synthesis; 24 h; Enzymatic reaction; regioselective reaction;
参考文献
RSC Advances, , vol. 4, # 19 p. 9673 - 9679
反应条件
potassium carbonate T=200°C; P=36775.4 Torr;
参考文献
Monatshefte fuer Chemie, , vol. 80, p. 197,199
反应条件
sodium dithionite in water T=37°C; pH=5; 1 h; aq. buffer;
参考文献
Journal of the American Chemical Society, , vol. 132, # 50 p. 17707 - 17709
反应条件
sodium dithionite in water T=37°C; pH=5; 1 h; aq. buffer;
参考文献
Journal of the American Chemical Society, , vol. 132, # 50 p. 17707 - 17709
反应条件
hydrogenchloride; tin
参考文献
Gazzetta Chimica Italiana, , vol. 59, p. 216
