美沙啦嗪(5-氨基水杨酸)合成路线 （共 91 条）
反应条件
1.1: sodium hydroxide; sodium nitrite / water / 5 °C 1.2: 5 °C 1.3: 1 h / 20 °C / |Inert atmosphere 2.1: potassium hydroxide / ethanol / 5 h View Scheme
参考文献
Saphier, Sigal; Haft, Avital; Margel, Shlomo
Journal of Medicinal Chemistry, 2012 , vol. 55, # 23 p. 10781 - 10785
反应条件
Oxonereg;; sodium hydroxide in water; acetone T=8°C; buffer (NaHCO3);
参考文献
Webb, Kevin S.; Seneviratne, Viran
Tetrahedron Letters, 1995 , vol. 36, # 14 p. 2377 - 2378
反应条件
durch Destillation mit Bimssteinpulver;
参考文献
Schmitt
Chemische Berichte, 1868 , vol. 1, p. 67
Full Text Show Details
Schmitt
Journal of the Chemical Society, 1864 , vol. 17, p. 194
Jahresbericht ueber die Fortschritte der Chemie und Verwandter Theile Anderer Wissenschaften, 1864 , p. 423
反应条件
bei der trocknen Destillation;
参考文献
Schmitt
Chemische Berichte, 1868 , vol. 1, p. 67
Full Text Show Details
Schmitt
Journal of the Chemical Society, 1864 , vol. 17, p. 194
Jahresbericht ueber die Fortschritte der Chemie und Verwandter Theile Anderer Wissenschaften, 1864 , p. 423
反应条件
polyphosphoric acid T=180°C; 5 h;
参考文献
Santos, Rosane Catarina Dos; Faleiro, Nalva Vivian Da Silva; Campo, Leandra Franciscato; Scroferneker, Maria Lucia; Corbellini, Valeriano Antonio; Rodembusch, Fabiano Severo; Stefani, Valter
Tetrahedron Letters, 2011 , vol. 52, # 23 p. 3048 - 3053
反应条件
acetic acid 2 h; Heating / reflux;
参考文献
MYRIAD GENETICS, INC.
Patent: WO2007/115306 A2, 2007 ;
Location in patent: Page/Page column 136-137 ;
反应条件
acetic acid T=150°C; Paal-Knorr pyrrole synthesis; 0.166667 h; Microwave irradiation;
参考文献
Liu, Kun; Lu, Hong; Hou, Ling; Qi, Zhi; Teixeira, Catia; Barbault, Florent; Fan, Bo-Tao; Liu, Shuwen; Jiang, Shibo; Xie, Lan
Journal of Medicinal Chemistry, 2008 , vol. 51, # 24 p. 7843 - 7854
反应条件
in chloroform 2 h; Heating / reflux;
参考文献
ANTIBE THERAPEUTICS INC.
Patent: US2008/207564 A1, 2008 ;
Location in patent: Page/Page column 12-13 ;
参考文献
Chen, Huixiong; Boiziau, Janine; Parker, Fabienne; Maroun, Rachid; Tocque, Bruno; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 25 p. 4094 - 4098
反应条件
1: methanol / Heating 2: NaBH3CN / methanol / 4 h / Ambient temperature View Scheme
参考文献
Chen, Huixiong; Boiziau, Janine; Parker, Fabienne; Maroun, Rachid; Tocque, Bruno; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 25 p. 4094 - 4098
