美沙啦嗪(5-氨基水杨酸)合成路线 （共 91 条）
反应条件
in ethanol 6 h; Heating;
参考文献
Agrawal, Vijai K.; Sharma, Satyavan
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1987 , vol. 26, # 1-12 p. 550 - 555
反应条件
1: With triethylamine in tetrahydrofuran; water T=20°C; 17 h; 2: With iodine in tetrahydrofuran; water T=0°C; 2.58333 h; 3: With hydrogenchloride in tetrahydrofuran; water
参考文献
Nissan Chemical Industries, Ltd.
Patent: EP2248800 A1, 2010 ;
Location in patent: Page/Page column 10 ;
反应条件
1: 90.3 percent / propan-1-ol / 1 h / 100 °C 2: 87 percent / HCl / dioxane / 3 h / 90 °C View Scheme
参考文献
Van Boi, Luu; Al-Ebaisat
Russian Chemical Bulletin, 1999 , vol. 48, # 12 p. 2290 - 2293
参考文献
Minister of Health and Welfare
Patent: US5840966 A1, 1998 ;
参考文献
Raiziss; Clemence
Journal of the American Chemical Society, 1930 , vol. 52, p. 2019,2022
反应条件
1: 52 percent / polyphosphoric acid / 15 h / Heating
2: 57 percent / hydrobromic acid; aq. sodium nitrate; copper bromide / 5 h / 100 °C
View Scheme
参考文献
Lee, Jin Koo; Na, Jongho; Park, Won Ho; Lee, Tack Seung; Kwon, Yong Ku
Molecular Crystals and Liquid Crystals, 2004 , vol. 424, p. 245 - 251
反应条件
potassium carbonate in isopropyl mesylate; water
T=50°C; 96 h;
参考文献
Giuliani International Limited
Patent: US2009/118357 A1, 2009 ;
Location in patent: Page/Page column 10 ;
US 20090118357 A1
反应条件
potassium carbonate in ethanol; water
T=50°C; 96 h;
参考文献
Nogra Pharma Limited; NACCARI, Giancarlo; BARONI, Sergio
Patent: EP1910275 B1, 2013 ;
Location in patent: Paragraph 0048-0049 ;
参考文献
Weil; Traun; Marcel
Chemische Berichte, 1922 , vol. 55, p. 2664
反应条件
sodium amalgam; boric acid; sulphite
weiteres Reagens: Wasser; Hydrolyse der entstandenen Verbindung mit verd. Schwefelsaeure;
参考文献
Weil; Traun; Marcel
Chemische Berichte, 1922 , vol. 55, p. 2664
