1,4-二甲基-2-硝基苯合成路线 （共 51 条）
反应条件
1: nitric acid / sulfuric acid / 2 h / 0 °C 2: hydrogen / 15 Pd/C / methanol / 40 °C / Inert atmosphere View Scheme
参考文献
PHARMARESOURCES(SHANGHAI)CO., LTD.; CHEN, Ping; ZHOU, Ding; PRYDE, David; BELL, Andrew; LI, Tao; HE, Zhiliang; CAI, Zhen-Wei
Patent: WO2012/65062 A1, 2012 ;
反应条件
1: ethanolic sodium ethylate 2: Na2S2O4; aqueous NaOH 3: 240 °C 4: acetic acid View Scheme
参考文献
Snyder; Pilgrim
Journal of the American Chemical Society, 1948 , vol. 70, p. 3787
反应条件
1: 92 percent / 85percent hydrazine hydrate / Raney-Ni / ethanol / 1 h / 90 °C 2: 1) NaNO2, HCl, NaBF4 / 1) water, 25 deg C, 1h, 2) Δ 3: SO2Cl2 / azobisisobutyronitrile / 9 h / 100 °C View Scheme
参考文献
Xinzhuo Zou; Keqan Gu
Journal of Fluorine Chemistry, 1990 , vol. 46, # 3 p. 507 - 513
反应条件
1: 92 percent / 85percent hydrazine hydrate / Raney-Ni / ethanol / 1 h / 90 °C 2: 1) NaNO2, HCl, NaBF4 / 1) water, 25 deg C, 1h, 2) Δ 3: SO2Cl2 / azobisisobutyronitrile / 9 h / 100 °C View Scheme
参考文献
Xinzhuo Zou; Keqan Gu
Journal of Fluorine Chemistry, 1990 , vol. 46, # 3 p. 507 - 513
反应条件
1: alcoholic water; zinc dust; ammonium chloride / 60 - 70 °C View Scheme
参考文献
Bamberger
Chemische Berichte, 1926 , vol. 59, p. 423
反应条件
chlorosulfonic acid; sodium chloride
参考文献
Winchester; Popp
Journal of Heterocyclic Chemistry, 1975 , vol. 12, # 3 p. 547 - 549
反应条件
sulfuric acid Electrolysis.Reduktion;
参考文献
le Guyader,M.
Bulletin de la Societe Chimique de France, 1966 , p. 1848 - 1858
反应条件
1: ethanolic sodium ethylate 2: Na2S2O4; aqueous NaOH View Scheme
参考文献
Snyder; Pilgrim
Journal of the American Chemical Society, 1948 , vol. 70, p. 3787
反应条件
hydrazine hydrate; Raney nickel in methanol; water T=0°C; 2 h;
参考文献
PHARMARESOURCES(SHANGHAI)CO., LTD.; CHEN, Ping; ZHOU, Ding; PRYDE, David; BELL, Andrew; LI, Tao; HE, Zhiliang; CAI, Zhen-Wei
Patent: WO2012/65062 A1, 2012 ;
Location in patent: Page/Page column 46-47 ;
反应条件
Hydrogenation; Kinetics;
参考文献
Samuelsen et al.
Journal of the American Chemical Society, 1950 , vol. 72, p. 3872
