1,4-二甲基-2-硝基苯合成路线 （共 51 条）
反应条件
anschliessend Kochen mit wss. HCl;
参考文献
Hunter; Sprung
Journal of the American Chemical Society, 1931 , vol. 53, p. 1432,1435, 1440
参考文献
Lock
Chemische Berichte, 1940 , vol. 73, p. 1377,1381
参考文献
Crandall,E.W. et al.
Journal of Organic Chemistry, 1967 , vol. 32, p. 134 - 136
反应条件
1: 92 percent / 85percent hydrazine hydrate / Raney-Ni / ethanol / 1 h / 90 °C 2: 1) NaNO2, HCl, NaBF4 / 1) water, 25 deg C, 1h, 2) Δ View Scheme
参考文献
Xinzhuo Zou; Keqan Gu
Journal of Fluorine Chemistry, 1990 , vol. 46, # 3 p. 507 - 513
反应条件
potassium hydroxide; potassium hexacyanoferrate(III)
参考文献
Noyes
American Chemical Journal, 1888 , vol. 10, p. 474,483
反应条件
1.1: hydrazine hydrate / Raney nickel / water; methanol / 2 h / 0 °C 2.1: hydrogenchloride; sodium nitrite / water / 1 h / 0 - 5 °C 2.2: 0 - 20 °C 2.3: 0 °C View Scheme
参考文献
PHARMARESOURCES(SHANGHAI)CO., LTD.; CHEN, Ping; ZHOU, Ding; PRYDE, David; BELL, Andrew; LI, Tao; HE, Zhiliang; CAI, Zhen-Wei
Patent: WO2012/65062 A1, 2012 ;
反应条件
1: 1.) Triton B, 2.) Zn, CaCl2 / 1.) Me2SO, 95 deg C, 1 h, 2.) H2O, reflux 2: 80 percent / RuCl2(PPh3)3 / toluene / 6 h / Heating View Scheme
参考文献
Snyder; Pilgrim
Journal of the American Chemical Society, 1948 , vol. 70, p. 3787
反应条件
1: With pyrrolidine in N,N-dimethyl-formamide T=100°C; Leimgruber-Batcho indole synthesis; 8 h; Inert atmosphere; 2: With FeCl3·6H2O; carbon; hydrazine hydrate in ethanol T=75°C; Leimgruber-Batcho indole synthesis; 5 h;
参考文献
Taydakov; Dutova; Sidorenko; Krasnoselsky
Chemistry of Heterocyclic Compounds, 2011 , vol. 47, # 4 p. 425 - 434
反应条件
ammonium chloride; water; zinc T=60 - 70°C;
参考文献
Brand; Mahr
Journal fuer Praktische Chemie (Leipzig), 1935 , vol. <2> 142, p. 153,166
反应条件
iridium in methanol; sulfuric acid
参考文献
Takeda Chemical Industries, Ltd.
Patent: EP1211253 B1, 2004 ;
