4-甲基-2-硝基苯胺合成路线 （共 173 条）
反应条件
1: conc. aq. HCl, NaNO2 / H2O / 0.25 h / -5 - 2 °C 2: LiCl, CuCl*2H2O / H2O; acetone / 1.) 2 h, 3 to 10 deg C, 2.) 2 h, 10 deg C to room temp., 3.) 2 h, room temp. 3: Fe, HOAc, sodium acetate dihydrate / ethanol; H2O / 2 h / Heating View Scheme
参考文献
Raucher, Stanley; Koolpe, Gary A.
Journal of Organic Chemistry, 1983 , vol. 48, # 12 p. 2066 - 2069
反应条件
1: 94 percent / Br2 / acetic acid / 1.) 15 deg C, 30 min, 2.) r.t., 1 h 2: 1.) conc. H2SO4, NaNO2, 2.) 50percent H3PO2, Cu2O / 1.) H2O, -2 deg C - -3 deg C, 2 h, 2.) H2O, -5 deg C, 90 min; 0 deg C, 10 min 3: 59 percent / dimethylformamide / 6 h / Heating View Scheme
参考文献
Fisher; Dershem; Prewitt
Journal of Organic Chemistry, 1990 , vol. 55, # 3 p. 1040 - 1043
反应条件
1: 94 percent / Br2 / acetic acid / 1.) 15 deg C, 30 min, 2.) r.t., 1 h 2: 1.) conc. H2SO4, NaNO2, 2.) 50percent H3PO2, Cu2O / 1.) H2O, -2 deg C - -3 deg C, 2 h, 2.) H2O, -5 deg C, 90 min; 0 deg C, 10 min 3: 59 percent / dimethylformamide / 6 h / Heating 4: 75 percent / 75percent H2SO4 / H2O / 1 h / 150 °C View Scheme
参考文献
Adams; Rinehart
Journal of Antibiotics, 1994 , vol. 47, # 12 p. 1456 - 1465
反应条件
1: acetic acid / 20 °C 2: N-bromosuccinmide; tetrachloromethane / |Reflux View Scheme
参考文献
Porcal, Williams; Merlino, Alicia; Boiani, Mariana; Gerpe, Alejandra; Gonzalez, Mercedes; Cerecetto, Hugo
Organic Process Research and Development, 2008 , vol. 12, # 2 p. 156 - 162
反应条件
potassium carbonate in N,N-dimethyl-formamide T=150°C; 37 h;
参考文献
Piotrovskii, L.B.; Poznyakova, L.N.
Journal of Organic Chemistry USSR (English Translation), 1982 , vol. 18, p. 1691 - 1695
Zhurnal Organicheskoi Khimii, 1982 , vol. 18, # 9 p. 1931 - 1935
反应条件
copper; potassium carbonate T=200°C;
参考文献
Vanicek; Allan
Chemicke Listy, 1954 , vol. 48, p. 1705
Collection of Czechoslovak Chemical Communications, 1955 , vol. 20, p. 996
Chem.Abstr., 1955 , p. 14733
反应条件
sodium hydroxide; sodium hypochlorite in ethanol; water 0.666667 h;
参考文献
CMAX OTIMIZACAO DE RESULTADOS S C LTDA
Patent: WO2006/42387 A1, 2006 ;
Location in patent: Page/Page column 9-10 ;
反应条件
1: 89 percent / K2S2O8, H2SO4 / 24 h 2: 8 g / aq. HNO3 / 0.08 h 3: 75 percent / CrO3, aq. H2SO4 / 1.) 35 deg C, 0.5 h, 2.) 45-55 deg C, 4 h 4: 1.) SOCl2, 2.) AlCl3 / 1.) reflux, 10 min, 2.) room temp., 24 h, then 40-50 deg C, 0.5 h View Scheme
参考文献
Dobrodei; El'tsov
Russian Journal of General Chemistry, 1998 , vol. 68, # 4 p. 620 - 629
参考文献
Gindraux
Helvetica Chimica Acta, 1929 , vol. 12, p. 932
反应条件
1.1: 29 percent / N-chlorosuccinimide / acetonitrile / Heating 2.1: sulfuric acid; aq. sodium nitrite / ethanol / 0.5 h / 0 - 20 °C 2.2: 69 percent / ethanol; H2O / Heating View Scheme
参考文献
Grella; Danso-Danquah; Safo; Joshi; Kister; Marden; Hoffman; Abraham
Journal of Medicinal Chemistry, 2000 , vol. 43, # 25 p. 4726 - 4737
