4-甲基-2-硝基苯胺合成路线 （共 173 条）
反应条件
1: Diazotization.Erwaermen der Diazoniumsulfatloesung mit KI auf dem Wasserbade 2: alcohol; iron monoxide hydrate 3: Diazotization.Behandlung der Diazoniumchloridloesung mit KI View Scheme
参考文献
Willgerodt; Simonis
Chemische Berichte, 1906 , vol. 39, p. 269
反应条件
P(OEt)3 in alcoholic sodium hydroxide; ethanol; water
参考文献
Synaptic Pharmaceutical Corporation
Patent: US6268369 B1, 2001 ;
US 6268369 B1
反应条件
1: Diazotization.Erwaermen der Diazoniumsulfatloesung mit KI auf dem Wasserbade 2: alcohol; iron monoxide hydrate 4: benzene; acetic acid; calcium chloride 5: alcoholic potash 6: ueber 2.5-(=3.6)-Dichlor-4-jod-toluol und 2.5-Dichlor-4-jod-benzoesaeure View Scheme
参考文献
Willgerodt; Simonis
Chemische Berichte, 1906 , vol. 39, p. 269
反应条件
sodium hypochlorite; sodium hydroxide in ethanol; water T=4°C; 0.666667 h;
参考文献
de Carvalho, Paulo Sergio; Marostica, Marta; Gambero, Alessandra; Pedrazzoli Jr., Jose
European Journal of Medicinal Chemistry, 2010 , vol. 45, # 6 p. 2489 - 2493
反应条件
acetic acid; benzene
参考文献
Pausacker; Scroggie
Australian Journal of Chemistry, 1958 , vol. 11, p. 485,487
反应条件
1: 1-amino-2-nitro-4-methylbenzene 2: MCN Sandmeyer cyanation; Further stages.;
参考文献
Chandler, Stephen A.
Journal of the Chemical Society, Perkin Transactions 2, 2001 , # 2 p. 214 - 228
反应条件
1: 1-amino-2-nitro-4-methylbenzene With hydrogenchloride; sodium acetate; copper(II) sulfate; sodium sulfite; sodium nitrite in water T=0°C; 2: formaldehyd With hydroxylamine hydrochloride; sodium acetate in water 3: With hydrogenchloride in water Reflux;
参考文献
Yamakawa, Naoki; Suemasu, Shintaro; Matoyama, Masaaki; Tanaka, Ken-Ichiro; Katsu, Takashi; Miyata, Keishi; Okamoto, Yoshinari; Otsuka, Masami; Mizushima, Tohru
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 11 p. 3299 - 3311
反应条件
1: 1.) NaNO2, conc. aq. HCl / 1.) H2O, 30 min, 2.) H2O, 1.5 h 2: aq. HCl / Heating View Scheme
参考文献
Wani; Nicholas; Manikumar; Wall
Journal of Medicinal Chemistry, 1987 , vol. 30, # 10 p. 1774 - 1779
反应条件
1: 1-amino-2-nitro-4-methylbenzene With hydrogenchloride; C25H20N6O6S2; sodium nitrite in water T=10°C; 1 h; 2: 1-(N-phenylcarbamyl)propan-2-one With sodium acetate; acetic acid in water T=25 - 90°C; pH=6; 2.5 h;
参考文献
Sanyo Color Works, Ltd.
Patent: EP1424370 A1, 2004 ;
Location in patent: Page 12 ;
反应条件
1: o-tolidine-6,6'-disulfonic acid; 1-amino-2-nitro-4-methylbenzene With hydrogenchloride; sodium nitrite in water T=10°C; 1 h; 2: 1-(N-phenylcarbamyl)propan-2-one With sodium hydroxide; sodium acetate; acetic acid in water T=25 - 90°C; pH=6; 2.5 h;
参考文献
Sanyo Color Works, Ltd.
Patent: EP1424370 A1, 2004 ;
Location in patent: Page 11 ;
