4-甲基-2-硝基苯胺合成路线 （共 173 条）
反应条件
1: Raney Ni, H2 / ethanol
2: 38 percent / NH3, H2S / H2O / 0.75 h / 45 - 55 °C
View Scheme
参考文献
El'tsov; Selitrenikov; Rtishchev
Russian Journal of General Chemistry, 1997 , vol. 67, # 2 p. 285 - 294
反应条件
1: Raney nickel; benzene / Hydrogenation
2: sodium acetate; aqueous acetic acid
3: platinum; benzene / 2206.5 - 4413.05 Torr / Hydrogenation
View Scheme
参考文献
Cavagnol; Wiselogle
Journal of the American Chemical Society, 1947 , vol. 69, p. 795,796
反应条件
1: SnCl2 / methanol / 3 h / Heating
2: nitrobenzene / 2 h / Heating
View Scheme
参考文献
Garuti, Laura; Roberti, Marinella; Pizzirani, Daniela; Pession, Annalisa; Leoncini, Emanuela; Cenci, Valentina; Hrelia, Silvana
Farmaco, 2004 , vol. 59, # 8 p. 663 - 668
反应条件
1: glycerol T=160°C; 1 h;
2: 1-amino-2-nitro-4-methylbenzene With sulfuric acid; sodium iodide
T=150°C;
参考文献
NOSCIRA, S.A.; MEDINA PADILLA, Miguel; CASTRO MORERA, Ana; SANCHEZ-QUESADA, Jorge; GARCIA PALOMERO, Esther
Patent: WO2010/66832 A1, 2010 ;
Location in patent: Page/Page column 38-39 ;
反应条件
1: concentrated sulfuric acid; picric acid
2: alcoholic ammonium sulfide solution
View Scheme
参考文献
Noelting; Trautmann
Chemische Berichte, 1890 , vol. 23, p. 3655
反应条件
2: iron; diluted acetic acid
View Scheme
参考文献
Morgan; Scharff
Journal of the Chemical Society, 1914 , vol. 105, p. 122
反应条件
sodium hydroxide in toluene
T=20 - 70°C;
参考文献
Lee, Jee-Hyun; Thanigaimalai, Pillaiyar; Lee, Ki-Cheul; Bang, Seong-Cheol; Kim, Min-Seok; Sharma, Vinay Kumar; Yun, Cheong-Yong; Roh, Eunmiri; Kim, Youngsoo; Jung, Sang-Hun
Chemical and Pharmaceutical Bulletin, 2010 , vol. 58, # 7 p. 918 - 921
反应条件
sodium hydroxide in toluene
T=20 - 70°C;
参考文献
Lee, Jee-Hyun; Thanigaimalai, Pillaiyar; Lee, Ki-Cheul; Bang, Seong-Cheol; Kim, Min-Seok; Sharma, Vinay Kumar; Yun, Cheong-Yong; Roh, Eunmiri; Kim, Youngsoo; Jung, Sang-Hun
Chemical and Pharmaceutical Bulletin, 2010 , vol. 58, # 7 p. 918 - 921
参考文献
TEIJIN LIMITED
Patent: EP1505067 A1, 2005 ;
Location in patent: Page/Page column 380 ;
EP 1505067 A1
反应条件
1: Br2 / acetic acid
2: NaNO2, H2SO4 / ethanol
3: 60 percent / Zn, NaOH / ethanol
4: 25percent HCl / 60 °C
5: NaNO2, HCl
6: H3PO2
View Scheme
参考文献
Schmid, Rudolf; Cereghetti, Marco; Heiser, Bernd; Schoenholzer, Peter; Hansen, Hans-Juergen
Helvetica Chimica Acta, 1988 , vol. 71, p. 897 - 930
