4-甲基-2-硝基苯胺合成路线 （共 173 条）
反应条件
1: 120 - 130 °C
2: tin; hydrochloric acid
3: beim Aufbewahren an der Luft
View Scheme
参考文献
Leuckart; Hermann
Chemische Berichte, 1887 , vol. 20, p. 27
反应条件
1: 1.) NaNO2, conc. aq. HCl / 1.) H2O, 30 min, 2.) H2O, 1.5 h
2: aq. HCl / Heating
3: FeSO4*7H2O, conc. NH4OH / ethanol / Heating
View Scheme
参考文献
Wani; Nicholas; Manikumar; Wall
Journal of Medicinal Chemistry, 1987 , vol. 30, # 10 p. 1774 - 1779
反应条件
1: (i) aq. HCl, NaNO2, (ii) SO2, CuCl2*2H2O
2: aq. NH3 / CHCl3
3: Fe, aq. AcOH
View Scheme
参考文献
Hayman,D.F. et al.
Journal of Pharmacy and Pharmacology, 1962 , vol. 14, p. 522 - 533
反应条件
1: 1.) 6 N HCl, NaNO2; 2.) CuCl2 / 1.) H2O, -5 deg C, 1 h; 2.) H2O, 50-55 deg C
2: 83 percent / conc. H2SO4 / 7 h / Heating
3: 89 percent / hydrogen / 10percent Pd-C / acetic acid / Ambient temperature
4: 1.) 6 N HCl, NaNO2; 2.) NaN3 / 1.) -5 deg C, 1 h; 2.) H2O, r.t.
5: 77 percent / o-dichlorobenzene / 1 h / 160 - 170 °C
6: 86 percent / 10percent aq. NaOH / ethanol / 1 h / Heating
7: 82 percent / SOCl2 / benzene / 0.5 h / Heating
View Scheme
参考文献
Nakashima; Kawashima; Amanuma; Sota; Tanaka; Kameyama
Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 11 p. 4271 - 4280
反应条件
1: 120 - 130 °C
2: nitric acid
View Scheme
参考文献
Gattermann
Chemische Berichte, 1885 , vol. 18, p. 1487
参考文献
Sondhi, Sham M.; Johar, Monika; Singh, Nirupma; Dastidar, Sunanda G.
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2004 , vol. 43, # 1 p. 162 - 167
反应条件
1: 75 percent / cc. sulphuric acid, ZnCl2 / acetic acid
2: 67 percent / aq. sulphuric acid / acetic acid / 2.5 h / 100 °C
3: 83 percent / HCl / Heating
4: 46 percent / sodium ethoxide / ethanol; dimethylformamide / 2 h
5: 85 percent / cc. HCl / 4 h
6: 72 percent / aq.NH3
View Scheme
参考文献
Harvey, Ian W.; McFarlane, Michael D.; Moody, David J.; Smith, David M.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1988 , p. 681 - 690
反应条件
1: 75 percent / cc. sulphuric acid, ZnCl2 / acetic acid
2: 67 percent / aq. sulphuric acid / acetic acid / 2.5 h / 100 °C
View Scheme
参考文献
Harvey, Ian W.; McFarlane, Michael D.; Moody, David J.; Smith, David M.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1988 , p. 681 - 690
参考文献
Leuckart; Hermann
Chemische Berichte, 1887 , vol. 20, p. 27
Full Text Show Details
Ploechl
Chemische Berichte, 1886 , vol. 19, p. 10
反应条件
1.1: water / 1.5 h / 100 °C
2.1: indium; hydrogenchloride / water / 0.5 h / 100 °C
2.2: 0.5 h / 100 °C
View Scheme
参考文献
Kommi, Damodara N.; Kumar, Dinesh; Bansal, Rohit; Chebolu, Rajesh; Chakraborti, Asit K.
Green Chemistry, 2012 , vol. 14, # 12 p. 3329 - 3335
