4-甲基-2-硝基苯胺合成路线 （共 173 条）
反应条件
selenium; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine in toluene T=150°C; P=22800 Torr; 4 h;
参考文献
Wang, Xiaofang; Ling, Gang; Xue, Yan; Lu, Shiwei
European Journal of Organic Chemistry, 2005 , # 8 p. 1675 - 1679
反应条件
1: 75 percent / cc. sulphuric acid, ZnCl2 / acetic acid 2: 67 percent / aq. sulphuric acid / acetic acid / 2.5 h / 100 °C 3: 83 percent / HCl / Heating 4: 46 percent / sodium ethoxide / ethanol; dimethylformamide / 2 h 5: 85 percent / cc. HCl / 4 h 6: 72 percent / aq.NH3 7: 39 percent / 750 °C / 0.05 - 0.07 Torr View Scheme
参考文献
Harvey, Ian W.; McFarlane, Michael D.; Moody, David J.; Smith, David M.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1988 , p. 681 - 690
反应条件
sodium hydroxide in ethanol; water T=70°C; 2 h; Green chemistry;
参考文献
Pu, Shuai; Liang, Qiuxiang; Luo, Xi; Luo, Juan
Journal of Chemical Research, 2014 , vol. 38, # 2 p. 118 - 120
反应条件
10 Pd/C; hydrogen; acetic acid in methanol T=20°C; P=760.051 Torr; 8 h;
参考文献
Liu, Zheng; Li, Haihong; Zhao, Qingjie; Shen, Jingshan
Heterocycles, 2008 , vol. 75, # 8 p. 1907 - 1911
反应条件
1: 89 percent / K2S2O8, H2SO4 / 24 h 2: 8 g / aq. HNO3 / 0.08 h 3: 75 percent / CrO3, aq. H2SO4 / 1.) 35 deg C, 0.5 h, 2.) 45-55 deg C, 4 h View Scheme
参考文献
Langley
Organic Syntheses, 1955 , vol. Coll. Vol. III, p. 334,336
反应条件
1: With hydrogenchloride T=100°C; 0.166667 h; 2: With sodium nitrite in water T=0°C; 0.5 h; 3: With potassium iodide in water T=0 - 70°C; 2 h;
参考文献
Wetzel, Alexander; Gagosz, Fabien
Angewandte Chemie - International Edition, 2011 , vol. 50, # 32 p. 7354 - 7358
参考文献
Porcal, Williams; Merlino, Alicia; Boiani, Mariana; Gerpe, Alejandra; Gonzalez, Mercedes; Cerecetto, Hugo
Organic Process Research and Development, 2008 , vol. 12, # 2 p. 156 - 162
反应条件
n-ethyl morpholine in diethyl ether
参考文献
Novak, Michael; Kahley, Mary Jo; Lin, Jing; Kennedy, Sonya A.; James, Tishia G.
Journal of Organic Chemistry, 1995 , vol. 60, # 25 p. 8294 - 8304
参考文献
Ulffers; v.Janson
Chemische Berichte, 1894 , vol. 27, p. 99
反应条件
1: N-ethylmorpholine / diethyl ether 2: H2 / Pd/C / acetic acid / 2585.7 Torr View Scheme
参考文献
Green; Day
Journal of the American Chemical Society, 1942 , vol. 64, p. 1167,1170
