反应条件
1.1: N-bromsuccinimide; α,α'-azaisobutyronitrile / CHCl3 / 5 h / Heating 2.1: 51.9 g / acetone / 5 h / 60 °C 3.1: NaOMe / methanol / 0.5 h / 20 °C 3.2: 78.1 percent / methanol / 6 h / 80 °C 4.1: 80 percent / aq. NaOH / methanol / 5.5 h / 80 °C 5.1: H2 / Pd/C / ethyl acetate / 10 h / 20 °C / 3000.24 Torr View Scheme
参考文献
Laufer, Stefan A.; Ahrens, Gabriele M.; Karcher, Solveigh C.; Hering, Joerg S.; Niess, Raimund
Journal of Medicinal Chemistry, 2006 , vol. 49, # 26 p. 7912 - 7915
