2-氨基-4-氯苯甲酸合成路线 （共 117 条）
反应条件
1: trichlorophosphate / 0 °C / |Reflux
2: potassium iodide / pentan-1-ol / 160 °C
View Scheme
参考文献
Mao, Fei; Huang, Ling; Luo, Zonghua; Liu, Anqiu; Lu, Chuanjun; Xie, Zhiyong; Li, Xingshu
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 19 p. 5884 - 5892
反应条件
1: trichlorophosphate / 0 °C / |Reflux
2: potassium iodide / pentan-1-ol / 160 °C
View Scheme
参考文献
Mao, Fei; Huang, Ling; Luo, Zonghua; Liu, Anqiu; Lu, Chuanjun; Xie, Zhiyong; Li, Xingshu
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 19 p. 5884 - 5892
反应条件
1: dioxane / 1.5 h / 40 °C
2: 1,2-dimethoxy-ethane
3: dioxane / 1.5 h / 40 °C
4: NaH / dimethylformamide
View Scheme
参考文献
Baronnet; Callendret; Blanchard; et al.
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 3 p. 241 - 247
反应条件
1: 1.) aq. HCl, NaNO2, 2.) Na2SO3 / 1.) <10 deg C, 30 min, 2.) H2O, RT, 2 h
2: conc. HCl / a) RT, overnight, b) 80 deg C, 6 h
3: 73 percent / pyridine / 2 h / Heating
View Scheme
参考文献
Wyrick, Steven D.; Voorstad, P. Josee; Cocolas, George; Hall, Iris H.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 6 p. 768 - 772
反应条件
1: 1.) aq. HCl, NaNO2, 2.) Na2SO3 / 1.) <10 deg C, 30 min, 2.) H2O, RT, 2 h
2: conc. HCl / a) RT, overnight, b) 80 deg C, 6 h
3: 73 percent / pyridine / 2 h / Heating
4: 1.) KOH / 1.) C2H5OH, 2.) C2H5OH, reflux, 6 h
5: 27 percent / KOH / ethanol / 4 h / Heating
View Scheme
参考文献
Wyrick, Steven D.; Voorstad, P. Josee; Cocolas, George; Hall, Iris H.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 6 p. 768 - 772
参考文献
Yoneda, Fumio; Koga, Masakazu
Journal of Heterocyclic Chemistry, 1989 , vol. 26, p. 49 - 53
反应条件
sodium hydroxide in water
T=60°C; 48 h;
参考文献
NYCOMED GMBH; BARTELS, Bjoern; WEINBRENNER, Steffen; MARX, Degenhard; DIEFENBACH, Joerg; DUNKERN, Torsten; MENGE, Wiro M.P.B.; CHRISTIAANS, Johannes A. M.
Patent: WO2010/15589 A1, 2010 ;
Location in patent: Page/Page column 107 ;
WO 2010/015589 A1
参考文献
Onyeibor, Onyeka; Croft, Simon L.; Dodson, Hilary I.; Feiz-Haddad, Mohammad; Kendrick, Howard; Millington, Nicola J.; Parapini, Silvia; Phillips, Roger M.; Seville, Scott; Shnyder, Steven D.; Taramelli, Donatella; Wright, Colin W.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 7 p. 2701 - 2709
反应条件
1: glacial acetic acid / Erwaermen auf 80grad
2: KOH-solution
View Scheme
参考文献
Heller; Hessel
Journal fuer Praktische Chemie (Leipzig), 1929 , vol. <2> 120, p. 69
反应条件
1.1: sodium nitrite; HCl / H2O / 0.08 h / 0 °C
1.2: 60 percent / potassium iodide / H2O / 0 - 90 °C
2.1: thionyl chloride; N,N-dimethylformamide / 2 h / Heating
View Scheme
参考文献
Gabbutt, Christopher D.; Heron, B. Mark; Instone, Alicia C.
Tetrahedron, 2006 , vol. 62, # 4 p. 737 - 745
