2-氨基-4-氯苯甲酸合成路线 （共 117 条）
反应条件
1: With sulfuric acid
72 h; Reflux;
2: With sodium hydrogencarbonate in ethanol; water
参考文献
Wadell, Göran; Edlund, Karin; Strand, Marten; Andersson, Emma; Öberg, Christopher; Elofsson, Mikael; Mei, Ya-Fang
Patent: US2013/210915 A1, 2013 ;
Location in patent: Paragraph 0303 ;
反应条件
thionyl chloride in benzene
4 h; Reflux;
参考文献
Jahng, Katherine Chae; Kim, Seung Ill; Kim, Dong Hyeon; Seo, Chang Seob; Son, Jong-Keun; Lee, Seung Ho; Lee, Eung Seok; Jahng, Yurngdong
Chemical and Pharmaceutical Bulletin, 2008 , vol. 56, # 4 p. 607 - 609
参考文献
Warner-Lambert Company
Patent: US5486512 A1, 1996 ;
US 5486512 A
参考文献
Jaen, Juan C.; Gregor, Vlad E.; Lee, Chet; Davis, Robert; Emmerling, Mark
Bioorganic and Medicinal Chemistry Letters, 1996 , vol. 6, # 6 p. 737 - 742
反应条件
tert.-butylnitrite in 1,4-dioxane; water; 1,2-dichloro-ethane
0.5 h; Heating; Yields of byproduct given;
参考文献
Rigby, James H.; Laurent, Stephane
Journal of Organic Chemistry, 1998 , vol. 63, # 19 p. 6742 - 6744
反应条件
sodium periodate; acetic acid; potassium iodide; sodium chloride in water
T=20°C; 8 h;
参考文献
Yu, Chao-Wu; Chang, Pei-Teh; Hsin, Ling-Wei; Chern, Ji-Wang
Journal of Medicinal Chemistry, 2013 , vol. 56, # 17 p. 6775 - 6791
反应条件
1: acetic acid
2: phosphorus (V)-chloride; benzene / Erhitzen des Reaktionsprodukts mit wss. Bromwasserstoffsaeure
View Scheme
参考文献
SANOFI
Patent: US2012/129864 A1, 2012 ;
