2-氨基-4-氯苯甲酸合成路线 （共 117 条）
反应条件
Diazotization.Einw. von CuCl und HCl auf das Diazotierungsprodukt;
参考文献
Cohn,P.
Monatshefte fuer Chemie, 1901 , vol. 22, p. 485
反应条件
potassium ethylxanthate; sodium nitrite Multistep reaction;
参考文献
Berryman; Edmunds; Bunker; Haleen; Bryant; Welch; Doherty
Bioorganic and Medicinal Chemistry, 1998 , vol. 6, # 9 p. 1447 - 1456
反应条件
benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide in N,N-dimethyl-formamide 18 h; Ambient temperature;
参考文献
Bartroli, Javier; Turmo, Enric; Alguero, Monica; Boncompte, Eulalia; Vericat, Maria L.; Conte, Lourdes; Ramis, Joaquim; Merlos, Manuel; Garcia-Rafanell, Julian; Forn, Javier
Journal of Medicinal Chemistry, 1998 , vol. 41, # 11 p. 1869 - 1882
反应条件
1: With hydrogenchloride; sodium hydroxide; sodium nitrite in water T=0 - 5°C; 0.5 h; 2: With potassium ethylxanthate in water T=75 - 80°C; 0.5 h; 3: With hydrogenchloride; sodium hydroxide; water; sodium hydrogensulfite more than 3 stages;
参考文献
Takeda Pharmaceutical Company Limited
Patent: EP1897880 A1, 2008 ;
Location in patent: Page/Page column 20 ;
反应条件
1: With sodium hydroxide; sodium nitrite in water T=10°C; 2: With hydrogenchloride in water T=10°C; 3: With ammonium hydroxide; hydroxylamine; copper(II) sulfate in water T=10 - 80°C;
参考文献
Zhang, Wanbin; Xie, Fang; Matsuo, Shigeaki; Imahori, Yuji; Kida, Toshiyuki; Nakatsuji, Yohji; Ikeda, Isao
Tetrahedron Asymmetry, 2006 , vol. 17, # 5 p. 767 - 777
反应条件
hydrogenchloride; sodium hydroxide in water T=20 - 30°C; pH=6.5; 5 h; Large scale;
参考文献
Goto, Shunsuke; Tsuboi, Hiroyuki; Kanoda, Masami; Mukai, Koji; Kagara, Kooji
Organic Process Research and Development, 2003 , vol. 7, # 5 p. 700 - 706
反应条件
sodium hydroxide anschliessend Behandeln mit Natriumcyanat und Essigsaeure;
参考文献
Curd et al.
Journal of the Chemical Society, 1948 , p. 1759,1765
反应条件
1: With hydrogenchloride; sodium nitrite in water T=0°C; 0.0833333 h; 2: With copper(I) bromide in water T=0 - 90°C;
参考文献
Gabbutt, Christopher D.; Heron, B. Mark; Instone, Alicia C.
Tetrahedron, 2006 , vol. 62, # 4 p. 737 - 745
反应条件
1: 2 h / 180 - 210 °C 2: 97.9 percent / POCl3, N,N-dimethylaniline / Heating View Scheme
参考文献
Curd et al.
Journal of the Chemical Society, 1948 , p. 1759,1765
反应条件
sulfuric acid 12 h; Heating;
参考文献
Cai, Sui Xiong; Zhou, Zhang-Lin; Huang, Jin-Cheng; Whittemore, Edward R.; Egbuwoku, Zizi O.; Lue, Yixin; Hawkinson, Jon E.; Woodward, Richard M.; Weber, Eckard; Keana, John F. W.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 17 p. 3248 - 3255
