2-氨基-4-氯苯甲酸合成路线 （共 117 条）
反应条件
hydrogenchloride T=50°C; 12 h;
参考文献
Theeraladanon, Chumpol; Arisawa, Mitsuhiro; Nishida, Atsushi; Nakagawa, Masako
Tetrahedron, 2004 , vol. 60, # 13 p. 3017 - 3035
反应条件
in methanol hydrogen chloride
参考文献
Ciba-Geigy Corporation
Patent: US3949081 A1, 1976 ;
Title/Abstract Full Text Show Details
Ciba-Geigy Corporation
Patent: US3989689 A1, 1976 ;
反应条件
in diethyl ether T=20°C; 1 h;
参考文献
Seong, Churl Min; Park, Woo Kyu; Park, Chul Min; Kong, Jae Yang; Park, No Sang
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 2 p. 738 - 743
反应条件
1: acetic acid 2: phosphorus (V)-chloride; benzene / Erhitzen des Reaktionsprodukts mit wss. Bromwasserstoffsaeure 4: sulfuric acid; nitric acid 5: aq.-ethanolic hydrochloric acid 6: aqueous HCl; aqueous H3PO2 / 0 °C View Scheme
参考文献
Atkinson; Simpson
Journal of the Chemical Society, 1947 , p. 232,236
反应条件
tert.-butylnitrite in 1,4-dioxane; water; 1,2-dichloro-ethane 0.5 h; Heating; Yields of byproduct given;
参考文献
Journal of Organic Chemistry, , vol. 63, # 19 p. 6742 - 6744
反应条件
1: 3 h / 110 - 120 °C 2: 78.4 percent / 25percent aq. NH3 / 1.) 0-5 deg C, 2) 48-50 deg C, 10 h View Scheme
参考文献
Yakhontov, L. N.; Zhikhareva, G. P.; Mastafanova, L. I.; Evstratova, M. I.; Pershin, G. N.; et al.
Pharmaceutical Chemistry Journal, 1987 , vol. 21, # 1 p. 34 - 45
Khimiko-Farmatsevticheskii Zhurnal, 1987 , vol. 21, # 1 p. 38 - 49
反应条件
1: 1.) aq. HCl, NaNO2, 2.) Na2SO3 / 1.) <10 deg C, 30 min, 2.) H2O, RT, 2 h 2: conc. HCl / a) RT, overnight, b) 80 deg C, 6 h View Scheme
参考文献
Leonard; Boyd; Herbrandson
Journal of Organic Chemistry, 1947 , vol. 12, p. 47,52
反应条件
ammonia; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine in methanol; N,N-dimethyl-formamide T=20°C; 96 h;
参考文献
AMBIT BIOSCIENCES CORPORATION; LIU, Gang; CHAO, Qi; HADD, Michael, J.; HOLLADAY, Mark, W.; ABRAHAM, Sunny; SETTI, Eduardo
Patent: WO2010/99379 A1, 2010 ;
Location in patent: Page/Page column 142 ;
反应条件
DIEA; benzotriazol-1-ol in N,N-dimethyl-formamide
参考文献
AMBIT BIOSCIENCES CORP.
Patent: US2012/53176 A1, 2012 ;
US 20120053176 A1
反应条件
ammonium hydroxide; triethylamine in dichloromethane
参考文献
Japan Energy Corporation
Patent: EP1229025 A1, 2002 ;
