2-氨基-4-氯苯甲酸合成路线 （共 117 条）
反应条件
1: V methoxymethyl ester / Reflux 2: sulfuric acid; nitric acid / 1 h / 100 °C View Scheme
参考文献
Carmi, Caterina; Galvani, Elena; Vacondio, Federica; Rivara, Silvia; Lodola, Alessio; Russo, Simonetta; Aiello, Stefania; Bordi, Fabrizio; Costantino, Gabriele; Cavazzoni, Andrea; Alfieri, Roberta R.; Ardizzoni, Andrea; Petronini, Pier Giorgio; Mor, Marco
Journal of Medicinal Chemistry, 2012 , vol. 55, # 5 p. 2251 - 2264
反应条件
1: With hydrogenchloride; sodium nitrite in water T=0°C; 0.0833333 h; 2: With potassium iodide in water T=0 - 90°C;
参考文献
Gabbutt, Christopher D.; Heron, B. Mark; Instone, Alicia C.
Tetrahedron, 2006 , vol. 62, # 4 p. 737 - 745
反应条件
1: 1.) NaNO2, conc. aq. HCl, 2.) NH2OH*HCl, aq. NaOH, aq. NH3, CuSO4 / 1.) 0 deg C, 1 h, 2.) from 0 deg C to boil 2: Ac2O / 0.25 h / Heating 3: 0.5 h / 400 °C View Scheme
参考文献
Guinot, Stephane G. R.; Hepworth, John D.; Wainwright, Mark
Journal of Chemical Research, Miniprint, 1997 , # 6 p. 1252 - 1261
反应条件
1.1: tetrahydrofuran / 2 h / 20 °C / |Inert atmosphere 2.1: 5 h / 100 °C / |Inert atmosphere 3.1: toluene / 3 h / |Inert atmosphere; |Dean-Stark; |Reflux 3.2: 5 h / |Inert atmosphere; |Dean-Stark; |Reflux 4.1: sodium acetate; acetic acid; bromine / 4 h / 45 °C / |Inert atmosphere 5.1: sodium azide / N,N-dimethyl-formamide / 5 h / 45 °C / |Inert atmosphere 6.1: zinc; ammonium chloride / ethyl acetate; methanol / 0.5 h / 20 - 60 °C / |Inert atmosphere 7.1: (2R,3S)-(-)-di-O-benzoyl tartaric acid / isopropyl alcohol / 18 h / 20 - 85 °C / |Inert atmosphere View Scheme
参考文献
Holland, Jason P.; Jones, Michael W.; Cohrs, Susan; Schibli, Roger; Fischer, Eliane
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 2 p. 496 - 507
参考文献
Bembenek, Scott D.; Hocutt, Frances M.; Leonard, JR., Barry Eastman; Rabinowitz, Michael H.; Rosen, Mark D.; Tarantino, Kyle T.; Venkatesan, Hariharan
Patent: US2010/204226 A1, 2010 ;
Location in patent: Page/Page column 22 ;
反应条件
1: aq. NaOH solution / anschliessend Behandeln mit Natriumcyanat und Essigsaeure 2: aqueous HCl View Scheme
参考文献
Hoffmann-La Roche Inc.
Patent: US5688803 A1, 1997 ;
反应条件
acetic acid in polyethyleneglycol (PEG-400) T=20 - 60°C; 0.166667 h;
参考文献
Sharafi-Kolkeshvandi, Mahnaz; Nikpour, Farzad
Chinese Chemical Letters, 2012 , vol. 23, # 4 p. 431 - 433
反应条件
sodium hydroxide in water T=28 - 60°C; pH=6.5 - 6.9; 5.5 h;
参考文献
Fujisawa Pharmaceutical Co., Ltd.
Patent: US6344559 B1, 2002 ;
Location in patent: Page column 4 ;
反应条件
in ethanol 4 h; Heating;
参考文献
Lakhan; Singh
Farmaco, Edizione Scientifica, 1988 , vol. 43, # 9 p. 745 - 751
反应条件
potassium carbonate; chloroacetic acid
参考文献
C.D. Searle and Co.
Patent: US5137910 A1, 1992 ;
