2-氨基-4-氯苯甲酸合成路线 （共 117 条）
反应条件
1: (i) NaNO2, aq. HCl, (ii) KI, aq. H2SO4 2: aq. KOH / Cu View Scheme
参考文献
Pelz,K. et al.
Collection of Czechoslovak Chemical Communications, 1968 , vol. 33, # 6 p. 1852 - 1872
反应条件
1: 2 h / |Reflux 2: sulfuric acid; nitric acid / 50 - 90 °C 3: phosphorus pentachloride / 3 h / 160 °C View Scheme
参考文献
Buha, Vipul M.; Rana, Dharmaraj N.; Chhabria, Mahesh T.; Chikhalia, Kishor H.; Mahajan, Bhushan M.; Brahmkshatriya, Pathik S.; Shah, Nisha K.
Medicinal Chemistry Research, 2013 , vol. 22, # 9 p. 4096 - 4109
反应条件
1: 100 percent / DCC, aq. HOBT, NEt3 / dimethylformamide / 18 h / Ambient temperature 2: 5N aq. HCl / dioxane; various solvent(s) / 18 h / 110 °C View Scheme
参考文献
Bartroli, Javier; Turmo, Enric; Alguero, Monica; Boncompte, Eulalia; Vericat, Maria L.; Conte, Lourdes; Ramis, Joaquim; Merlos, Manuel; Garcia-Rafanell, Julian; Forn, Javier
Journal of Medicinal Chemistry, 1998 , vol. 41, # 11 p. 1869 - 1882
反应条件
sodium azide; ammonium chloride; trichlorophosphate; N,N-dimethyl-formamide T=0 - 20°C; Curtius rearrangement;
参考文献
Synthetic Communications, , vol. 34, # 4 p. 735 - 742
反应条件
1: 1.) 120 deg C, 2 h; 2.) 170 deg C, 2 h 2: PCl5 / POCl3 / 2 h / Heating View Scheme
参考文献
CUREGENIX INC.; AN, Songzhu; LI, Chufang; HUANG, Chen; ZHOU, Guisheng
Patent: WO2012/88712 A1, 2012 ;
反应条件
1: acetic acid 2: phosphorus (V)-chloride; benzene / Erhitzen des Reaktionsprodukts mit wss. Bromwasserstoffsaeure 4: sulfuric acid; nitric acid 5: aq.-ethanolic hydrochloric acid 6: aqueous HCl / anschliessendes Behandeln mit wss. H3PO2 bei 0grad View Scheme
参考文献
Atkinson; Simpson
Journal of the Chemical Society, 1947 , p. 232,236
参考文献
Wang, Yan; Jia, Shaojuan; Tseng, Ben; Drewe, John; Cai, Sui Xiong
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 22 p. 6178 - 6182
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
T=0 - 20°C; Inert atmosphere;
参考文献
Jia, Min-Qiang; You, Shu-Li
ACS Catalysis, 2013 , vol. 3, # 4 p. 622 - 624
反应条件
sodium hydroxide; hydrogen in tetrahydrofuran; water; Petroleum ether
参考文献
Sandoz, Inc.
Patent: US4164407 A1, 1979 ;
反应条件
1: Na2CO3
2: Na2CO3
3: Et3N / Heating
View Scheme
参考文献
Onyeibor, Onyeka; Croft, Simon L.; Dodson, Hilary I.; Feiz-Haddad, Mohammad; Kendrick, Howard; Millington, Nicola J.; Parapini, Silvia; Phillips, Roger M.; Seville, Scott; Shnyder, Steven D.; Taramelli, Donatella; Wright, Colin W.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 7 p. 2701 - 2709
