2-氨基-4-氯苯甲酸合成路线 （共 117 条）
反应条件
1: chloroacetic acid; 4-chloro-2-amino-benzoic acid With sodium hydroxide in water
Heating;
2: acetic anhydride With sodium acetate in water; N,N-dimethyl-formamide
Heating;
参考文献
Nirogi, Ramakrishna V.S.; Deshpande, Amol D.; Kambhampati, Ramasastri; Badange, Rajesh Kumar; Kota, Laxman; Daulatabad, Anand V.; Shinde, Anil K.; Ahmad, Ishtiyaque; Kandikere, Vishwottam; Jayarajan, Pradeep; Dubey
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 1 p. 346 - 349
反应条件
1.1: sodium hydroxide; hydrogenchloride / water / 5 h / 20 - 30 °C / pH 6.5 / |Large scale
2.1: sodium hydroxide / water / 2 h / 60 - 65 °C / pH 6.5 / |Large scale
2.2: 2 h / 30 °C / pH 1 - 1.5 / |Large scale
3.1: potassium carbonate / N,N-dimethyl-formamide
View Scheme
参考文献
Goto, Shunsuke; Tsuboi, Hiroyuki; Kanoda, Masami; Mukai, Koji; Kagara, Kooji
Organic Process Research and Development, 2003 , vol. 7, # 5 p. 700 - 706
反应条件
1.1: tetrahydrofuran / Reflux
2.1: hydrogenchloride / ethanol / 70 °C
2.2: 5 °C
3.1: potassium carbonate / N,N-dimethyl-formamide
View Scheme
参考文献
Goto, Shunsuke; Tsuboi, Hiroyuki; Kanoda, Masami; Mukai, Koji; Kagara, Kooji
Organic Process Research and Development, 2003 , vol. 7, # 5 p. 700 - 706
反应条件
1: sulfuric acid
2: diphenyl ether
View Scheme
参考文献
Fuson; Burness
Journal of the American Chemical Society, 1946 , vol. 68, p. 1270
反应条件
isopentyl nitrite
1.) CHCl3, 15 min, reflux; 2.) dioxane 70 deg C; Multistep reaction;
参考文献
Gavina, F.; Luis, S. V.; Costero, A. M.
Tetrahedron, 1986 , vol. 42, # 1 p. 155 - 166
反应条件
1: With hydrogenchloride; sodium nitrite in water
2: With water; sodium sulfite
参考文献
Stiff, Cory; Graber, David R.; Thorarensen, Atli; Wakefield, Brian D.; Marotti, Keith R.; Melchior, Earline P.; Sweeney, Michael T.; Han, Fusen; Rohrer, Douglas C.; Zurenko, Gary E.; Romero, Donna L.
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 23 p. 6293 - 6297
反应条件
1: 4 h / |Reflux
2: acetic acid / 16 h / |Reflux
View Scheme
参考文献
Yu, Chao-Wu; Chang, Pei-Teh; Hsin, Ling-Wei; Chern, Ji-Wang
Journal of Medicinal Chemistry, 2013 , vol. 56, # 17 p. 6775 - 6791
反应条件
pyridine
Acylation; cyclization; condensation; 0.5 h;
参考文献
Osborne, Alan G.; Goolamali, Zia
Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2000 , vol. 56, # 6 p. 1079 - 1100
反应条件
1: toluene / 2 h / Reflux
2: [bis(acetoxy)iodo]benzene / acetonitrile / 0.5 h / 20 °C
View Scheme
参考文献
Xie, Yuanyuan; Wang, Suping
Journal of Chemical Research, 2012 , vol. 36, # 3 p. 123 - 126
反应条件
1: pyridine
2: concentrated sulfuric acid
View Scheme
参考文献
Heller; Hessel
Journal fuer Praktische Chemie (Leipzig), 1929 , vol. <2> 120, p. 69
