1,3-二甲基-4-硝基苯合成路线 （共 60 条）
反应条件
hydrogenchloride; RhCl(PPh3)3 competition with 2-nitro-o-xylene reduction, multistep reaction, 1.) toluene, 110 deg C, 10 min, 2.) methanol, room temperature, 2 h;
参考文献
Brinkman, Herbert R.; Miles, William H.; Hilborn, Michael D.; Smith, Michael C.
Synthetic Communications, 1996 , vol. 26, # 5 p. 973 - 980
参考文献
Bamberger
Chemische Berichte, 1926 , vol. 59, p. 423
反应条件
1: potassium permanganate / water / 90 °C 2: hydrogen / palladium 10 on activated carbon / tetrahydrofuran; methanol View Scheme
参考文献
NEUROTUNE AG; AHMED, Shaheen; HETTWER, Stefan; VRIJBLOED, Jan Willem; FARINA, Carlo; ALLGEIER, Hans
Patent: WO2012/59442 A2, 2012 ;
WO 2012/059442 A2
反应条件
1: CrO3, H2SO4 / acetic acid 2: H2SO4 / aq. ethanol 3: Al(OiPr)3 / propan-2-ol View Scheme
参考文献
Doleib,D.M.; Iskander,Y.
Journal of the Chemical Society [Section] B: Physical Organic, 1967 , p. 1154 - 1158
反应条件
1: permanganate 2: concentrated sulfuric acid View Scheme
参考文献
Axer
Monatshefte fuer Chemie, 1920 , vol. 41, p. 155
反应条件
1: permanganate 2: concentrated sulfuric acid 3: tin; concentrated hydrochloric acid View Scheme
参考文献
Axer
Monatshefte fuer Chemie, 1920 , vol. 41, p. 155
反应条件
1: With pyrrolidine in 1,4-dioxane T=102°C; Leimgruber-Batcho Indole Synthesis; 14 h; RefluxInert atmosphere; 2: With hydrazine hydrate in 1,4-dioxane T=45°C; Leimgruber-Batcho Indole Synthesis; 1 h;
参考文献
Chen, Jinchun; Zhang, Zhikai; Liu, Sujing; Yang, Cuiyun; Xia, Chuanhai
RSC Advances, 2014 , vol. 4, # 9 p. 4672 - 4675
反应条件
1: permanganate 2: 100 °C / im Rohr 3: tin; concentrated hydrochloric acid View Scheme
参考文献
NEUROTUNE AG; AHMED, Shaheen; HETTWER, Stefan; VRIJBLOED, Jan Willem; FARINA, Carlo; ALLGEIER, Hans
Patent: WO2012/59442 A2, 2012 ;
WO 2012/059442 A2
反应条件
1: potassium permanganate / water / 90 °C 2: hydrogen / palladium 10 on activated carbon / tetrahydrofuran; methanol 3: tetrahydrofuran / 24 h / Reflux View Scheme
参考文献
NEUROTUNE AG; AHMED, Shaheen; HETTWER, Stefan; VRIJBLOED, Jan Willem; FARINA, Carlo; ALLGEIER, Hans
Patent: WO2012/59442 A2, 2012 ;
WO 2012/059442 A2
反应条件
1: permanganate 2: 100 °C / im Rohr View Scheme
参考文献
NEUROTUNE AG; AHMED, Shaheen; HETTWER, Stefan; VRIJBLOED, Jan Willem; FARINA, Carlo; ALLGEIER, Hans
Patent: WO2012/59442 A2, 2012 ;
WO 2012/059442 A2
