2-(4-氟-苯基)-1H-咪唑-4-羧酸合成路线 （共 3 条）
反应条件
hydroxylamine hydrochloride; sodium hydroxide in methanol
T=80°C; 1 h;
参考文献
Kamal, Ahmed; Tamboli, Jaki R.; Vishnuvardhan; Adil; Nayak, V. Lakshma; Ramakrishna
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 1 p. 273 - 280
反应条件
1: sodium methylate / tetrahydrofuran / 8 h / 20 °C
2: acetic acid; hydrazine hydrate / 1 h / |Reflux
3: hydroxylamine hydrochloride; sodium hydroxide / methanol / 1 h / 80 °C
View Scheme
参考文献
Kamal, Ahmed; Tamboli, Jaki R.; Vishnuvardhan; Adil; Nayak, V. Lakshma; Ramakrishna
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 1 p. 273 - 280
反应条件
1: acetic acid; hydrazine hydrate / 1 h / |Reflux
2: hydroxylamine hydrochloride; sodium hydroxide / methanol / 1 h / 80 °C
View Scheme
参考文献
Kamal, Ahmed; Tamboli, Jaki R.; Vishnuvardhan; Adil; Nayak, V. Lakshma; Ramakrishna
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 1 p. 273 - 280
