2-甲基-4-硝基苯甲腈合成路线 （共 19 条）
反应条件
1: 4-amino-3-methyl-nitro-benzene With hydrogenchloride; sodium nitrite in water T=-5°C; 2: With sodium hydrogencarbonate in water T=-5 - 20°C; 3: potassium cyanide With copper (I) cyanide in water; ethyl acetate T=20°C;
参考文献
WARNER-LAMBERT COMPANY LLC
Patent: WO2004/69245 A1, 2004 ;
Location in patent: Page/Page column 109-110 ;
反应条件
tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl-formamide T=120°C; 24 h;
参考文献
GRÜNENTHAL GMBH; FRANK, Robert; BAHRENBERG, Gregor; CHRISTOPH, Thomas; LESCH, Bernhard; LEE, Jeewoo
Patent: WO2013/45451 A1, 2013 ;
Location in patent: Page/Page column 80 ;
反应条件
1: in DMF (N,N-dimethyl-formamide) T=145°C; 5 h; 2: With hydrogenchloride; anhydrous iron chloride in DMF (N,N-dimethyl-formamide); water T=60°C; 0.333333 h;
参考文献
Sumitomo Pharmaceuticals Company, Limited
Patent: EP1500643 A1, 2005 ;
Location in patent: Page 32 ;
EP 1500643 A1
反应条件
tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl-formamide T=120°C; 24 h;
参考文献
GRÜNENTHAL GMBH; FRANK, Robert; BAHRENBERG, Gregor; CHRISTOPH, Thomas; LESCH, Bernhard; LEE, Jeewoo
Patent: WO2013/45447 A1, 2013 ;
Location in patent: Page/Page column 67 ;
反应条件
1: 4-amino-3-methyl-nitro-benzene With hydrogenchloride; sodium nitrite T=0 - 5°C; Diazotization; 2: copper (I) cyanide With potassium cyanide in ethyl acetate T=20°C; Substitution;
参考文献
Rosowsky, Andre; Forsch, Ronald A.; Null, Allison; Moran, Richard G.
Journal of Medicinal Chemistry, 1999 , vol. 42, # 18 p. 3510 - 3519
反应条件
1: toluene-4-sulfonic acid; sodium nitrite; potassium iodide / acetonitrile; water / 4 h / 20 °C 2: tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 24 h / 120 °C View Scheme
反应条件
1: Fe, AcOH 2: (i) aq. NaNO2, H2SO4, (ii) CuBr View Scheme
参考文献
Galun,A.B. et al.
Journal of Organic Chemistry, 1962 , vol. 27, p. 1426 - 1430
反应条件
tin(IV) chloride in ethanol 3 h; Heating / reflux;
参考文献
Sumitomo Pharmaceuticals Company, Limited
Patent: EP1500643 A1, 2005 ;
Location in patent: Page 32 ;
EP 1500643 A1
参考文献
Gabriel; Thieme
Chemische Berichte, 1919 , vol. 52, p. 1083
反应条件
sodium hydroxide; permanganate(VII) ion
参考文献
Mayer,M.
Journal fuer Praktische Chemie (Leipzig), 1915 , vol. <2> 92, p. 149
