5-氯磺酰基-2-甲基苯甲酸合成路线 （共 6 条）
反应条件
chlorosulfonic acid T=50°C; 2 h;
参考文献
Yang, Yung-Lin; Rajagopal, Basker; Liang, Chien-Fu; Chen, Chun-Chi; Lai, Hsiu-Ping; Chou, Chih-Hung; Lee, Yen-Pin; Yang, Yen-Ling; Zeng, Jing-Wen; Ou, Chun-Lin; Lin, Po-Chiao
Tetrahedron, 2013 , vol. 69, # 12 p. 2640 - 2646
参考文献
PFIZER PRODUCTS INC.
Patent: WO2005/92845 A1, 2005 ;
Location in patent: Page/Page column 136 ;
WO 2005/092845 A1
反应条件
sulfur trioxide T=110°C;
反应条件
KHF2 in 1,4-dioxane; water T=20°C; 0.5 h; Inert atmosphere;
参考文献
Grimster, Neil P.; Connelly, Stephen; Baranczak, Aleksandra; Dong, Jiajia; Krasnova, Larissa B.; Sharpless, K. Barry; Powers, Evan T.; Wilson, Ian A.; Kelly, Jeffery W.
Journal of the American Chemical Society, 2013 , vol. 135, # 15 p. 5656 - 5668
反应条件
in dichloromethane; water
T=20°C; 18 h;
参考文献
Wyeth LLC
Patent: US2012/10205 A1, 2012 ;
Location in patent: Page/Page column 12 ;
US 20120010205 A1
反应条件
pyridine
T=0 - 20°C; Product distribution / selectivity;
参考文献
AGIOS PHARMACEUTICALS, INC.; SALITURO, Francesco, G.; SAUNDERS, Jeffrey, O.
Patent: WO2011/72174 A1, 2011 ;
Location in patent: Page/Page column 101-102 ;
WO 2011/072174 A1
