2-氧代-2-(1H-吡咯并[2,3-c]吡啶-3-基)乙酸乙酯合成路线 （共 2 条）
反应条件
1: 1H-pyrrolo[2,3-c]pyridine With AlCl3, aluminium chloride in dichloromethane
T=0°C; 0.5 h; Inert atmosphere;
2: oxalic acid monoethyl ester chloride in dichloromethane
T=0 - 20°C; Inert atmosphere;
参考文献
Ganser, Christopher; Lauermann, Eva; Maderer, Annett; Stauder, Torsten; Kramb, Jan-Peter; Plutizki, Stanislav; Kindler, Thomas; Moehler, Markus; Dannhardt, Gerd
Journal of Medicinal Chemistry, 2012 , vol. 55, # 22 p. 9531 - 9540
反应条件
1.1: tetrahydrofuran / 8 h / -78 °C / |Inert atmosphere
2.1: palladium 10 on activated carbon; hydrogen / ethanol / 8 h / 20 °C / 750.08 Torr / |Autoclave; |Alkaline conditions
3.1: AlCl3, aluminium chloride / dichloromethane / 0.5 h / 0 °C / |Inert atmosphere
3.2: 0 - 20 °C / |Inert atmosphere
View Scheme
参考文献
Ganser, Christopher; Lauermann, Eva; Maderer, Annett; Stauder, Torsten; Kramb, Jan-Peter; Plutizki, Stanislav; Kindler, Thomas; Moehler, Markus; Dannhardt, Gerd
Journal of Medicinal Chemistry, 2012 , vol. 55, # 22 p. 9531 - 9540
