sodium hydrogencarbonate in water; ethyl acetate Ambient temperature;

sodium hydride in N,N-dimethyl-formamide -50 deg C, up to 10 deg C;

1: 56 percent / 61 percent sodium hydride in paraffine / dimethylformamide / -50 deg C, up to 10 deg C 2: 84 percent / phosphoryl chloride / dimethylformamide / 0 deg C then rt. View Scheme

1: 56 percent / 61 percent sodium hydride in paraffine / dimethylformamide / -50 deg C, up to 10 deg C 2: 84 percent / phosphoryl chloride / dimethylformamide / 0 deg C then rt. 3: 87 percent / potassium hydroxide / methanol; H2O / Ambient temperature View Scheme