1-[3-(4-甲基苯基)-1,2,4-恶二唑-5-基]甲胺合成路线 （共 4 条）
反应条件
hydrazine hydrate in ethanol
0.5 h; Reflux;
参考文献
Ozcan, Sevil; Kazi, Aslamuzzaman; Marsilio, Frank; Fang, Bin; Guida, Wayne C.; Koomen, John; Lawrence, Harshani R.; Sebti, Said M.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 10 p. 3783 - 3805
反应条件
1: potassium carbonate / acetonitrile / 1 h / Reflux
2: hydrazine / ethanol / 0.5 h / Reflux
View Scheme
参考文献
H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.; LAWRENCE, Harshani R.; SEBTI, Said M.; OZCAN, Sevil
Patent: WO2012/129564 A2, 2012 ;
WO 2012/129564 A2
反应条件
1: toluene / 2 h / Reflux; Molecular sieve
2: potassium carbonate / acetonitrile / 1 h / Reflux
3: hydrazine / ethanol / 0.5 h / Reflux
View Scheme
参考文献
H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.; LAWRENCE, Harshani R.; SEBTI, Said M.; OZCAN, Sevil
Patent: WO2012/129564 A2, 2012 ;
WO 2012/129564 A2
反应条件
1: acetone / 0.5 h / 20 °C
2: toluene / 2 h / Reflux; Molecular sieve
3: potassium carbonate / acetonitrile / 1 h / Reflux
4: hydrazine / ethanol / 0.5 h / Reflux
View Scheme
参考文献
H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.; LAWRENCE, Harshani R.; SEBTI, Said M.; OZCAN, Sevil
Patent: WO2012/129564 A2, 2012 ;
WO 2012/129564 A2
