3,4-二氯-2-甲基氟苯合成路线 (共 5 条)
反应条件
1: 1,2-dichloro-4-fluorobenzene With N,N,N',N,-tetramethylethylenediamine; sec.-butyllithium in tetrahydrofuran
T=-78°C; 4 h;
2: methyl iodide in tetrahydrofuran
T=-78 - 20°C; Product distribution / selectivity;
参考文献
ASTRAZENECA AB
Patent: WO2006/62476 A1, 2006 ;
Location in patent: Page/Page column 4 ;
WO 2006/062476 A1
反应条件
1: 1,2-dichloro-4-fluorobenzene With n-butyllithium in tetrahydrofuran
T=-78 - -40°C; 0.5 h;
2: methyl trifluoromethanesulfonate in tetrahydrofuran
T=-78 - 20°C; Product distribution / selectivity;
参考文献
ASTRAZENECA AB
Patent: WO2006/62476 A1, 2006 ;
Location in patent: Page/Page column 4 ;
WO 2006/062476 A1
反应条件
1: 1,2-dichloro-4-fluorobenzene With n-butyllithium in tetrahydrofuran
T=-45 - -40°C;
2: dimethyl sulfate in tetrahydrofuran
T=-55 - 20.5°C; 0.5 h;
3: With ammonia; water in tetrahydrofuran
T=20 - 25°C; 0.5 h; Product distribution / selectivity;
参考文献
ASTRAZENECA AB
Patent: WO2006/62476 A1, 2006 ;
Location in patent: Page/Page column 5-6 ;
WO 2006/062476 A1
反应条件
1: 1,2-dichloro-4-fluorobenzene With lithium diisopropyl amide in tetrahydrofuran
T=-60 - -40°C; 0.833333 h;
2: dimethyl sulfate in tetrahydrofuran
T=-60 - 20°C;
3: With ammonia; water in tetrahydrofuran; diethyl ether
Product distribution / selectivity;
参考文献
ASTRAZENECA AB
Patent: WO2006/62476 A1, 2006 ;
Location in patent: Page/Page column 6-7 ;
WO 2006/062476 A1
反应条件
1: With n-butyllithium in tetrahydrofuran
T=-45 - 20°C; 1.25 - 1.66667 h;
2: With ammonia; water in tetrahydrofuran
0.5 h; Product distribution / selectivity;
参考文献
ASTRAZENECA AB
Patent: WO2006/62476 A1, 2006 ;
Location in patent: Page/Page column 3-4 ;
WO 2006/062476 A1