6-甲氧基-喹啉-2-甲醛合成路线 （共 8 条）
反应条件
formic acid; dihydrogen peroxide
参考文献
Ding, Ke; Chen, Jianyong; Ji, Min; Wu, Xihan; Varady, Judith; Yang, Chao-Yie; Lu, Yipin; Deschamps, Jeffrey R.; Levant, Beth; Wang, Shaomeng
Journal of Medicinal Chemistry, 2005 , vol. 48, # 9 p. 3171 - 3181
反应条件
selenium(IV) oxide in para-xylene
16 h; Inert atmosphereReflux;
参考文献
NATIONAL HEALTH RESEARCH INSTITUTES; TAIPEI MEDICAL UNIVERSITY
Patent: US2011/275643 A1, 2011 ;
Location in patent: Page/Page column 12 ;
反应条件
palladium diacetate; hydrogen; triphenylphosphine; 2,4,6-trimethyl-pyridine; tributyl-amine in acetonitrile
T=120°C; P=22501.8 Torr; 18 h;
参考文献
Holzapfel, Cedric W.; Ferreira, Alta C.; Marais, Wilhelmina
Journal of Chemical Research - Part S, 2002 , # 5 p. 218 - 220
反应条件
1: potassium carbonate / N,N-dimethyl-formamide / 24 h / 20 °C
2: selenium(IV) oxide / 1,4-dioxane / 5 h / 80 °C
View Scheme
参考文献
Zhao, Hua Yang; Li, Yi Ming; Gong, Tian Jun; Guo, Qing Xiang
Chinese Chemical Letters, 2011 , vol. 22, # 9 p. 1013 - 1016
反应条件
1: hydrogenchloride / water / 6 h / Reflux
2: potassium carbonate / N,N-dimethyl-formamide / 24 h / 20 °C
3: selenium(IV) oxide / 1,4-dioxane / 5 h / 80 °C
View Scheme
参考文献
Zhao, Hua Yang; Li, Yi Ming; Gong, Tian Jun; Guo, Qing Xiang
Chinese Chemical Letters, 2011 , vol. 22, # 9 p. 1013 - 1016
反应条件
1: polyphosphoric acid / 16.75 h / 80 - 120 °C
2: phosphorus tribromide / N,N-dimethyl-formamide / 3 h / 0 - 20 °C
3: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C
4: selenium(IV) oxide / 1,4-dioxane / 2 h / 80 °C
View Scheme
参考文献
Gopinath, Vadiraj S.; Pinjari, Jakir; Dere, Ravindra T.; Verma, Aditya; Vishwakarma, Preeti; Shivahare, Rahul; Moger, Manjunath; Kumar Goud, Palusa Sanath; Ramanathan, Vikram; Bose, Prosenjit; Rao; Gupta, Suman; Puri, Sunil K.; Launay, Delphine; Martin, Denis
European Journal of Medicinal Chemistry, 2013 , vol. 69, p. 527 - 536
反应条件
1: phosphorus tribromide / N,N-dimethyl-formamide / 3 h / 0 - 20 °C
2: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C
3: selenium(IV) oxide / 1,4-dioxane / 2 h / 80 °C
View Scheme
参考文献
Gopinath, Vadiraj S.; Pinjari, Jakir; Dere, Ravindra T.; Verma, Aditya; Vishwakarma, Preeti; Shivahare, Rahul; Moger, Manjunath; Kumar Goud, Palusa Sanath; Ramanathan, Vikram; Bose, Prosenjit; Rao; Gupta, Suman; Puri, Sunil K.; Launay, Delphine; Martin, Denis
European Journal of Medicinal Chemistry, 2013 , vol. 69, p. 527 - 536
反应条件
1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C
2: selenium(IV) oxide / 1,4-dioxane / 2 h / 80 °C
View Scheme
参考文献
Gopinath, Vadiraj S.; Pinjari, Jakir; Dere, Ravindra T.; Verma, Aditya; Vishwakarma, Preeti; Shivahare, Rahul; Moger, Manjunath; Kumar Goud, Palusa Sanath; Ramanathan, Vikram; Bose, Prosenjit; Rao; Gupta, Suman; Puri, Sunil K.; Launay, Delphine; Martin, Denis
European Journal of Medicinal Chemistry, 2013 , vol. 69, p. 527 - 536
