3-氨基-4-溴-1H-吡咯-2-羧酸乙酯合成路线 （共 2 条）
反应条件
bromine; acetic acid in water
T=20°C; 1 h;
参考文献
ASTRAZENECA AB
Patent: WO2006/62465 A1, 2006 ;
Location in patent: Page/Page column 62 ;
WO 2006/062465 A1
反应条件
1.1: 99 percent / 4-chloropyridine hydrochloride / dioxane / 100 °C
2.1: 43 percent / Heating
3.1: 99 percent / sodium hydride / dimethylformamide / 25 °C
4.1: phosphorus oxychloride / 70 °C
4.2: 86 percent / aq. sodium hydroxide / 80 °C
View Scheme
参考文献
Rochais; Lisowski; Dallemagne; Rault
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 24 p. 8162 - 8175
