2-氨基-5-氯-N,3-二甲基苯甲酰胺合成路线 （共 13 条）
反应条件
palladium diacetate; 1,4-di(diphenylphosphino)-butane in ethylene glycol T=25 - 110°C; P=2842.59 Torr; Inert atmosphereSealed tube;
参考文献
E. I. DU PONT DE NEMOURS AND COMPANY; KRISTJANSDOTTIR, Sigridur, Soley; SHAPIRO, Rafael; OBERHOLZER, Matthew, Richard
Patent: WO2012/103436 A1, 2012 ;
Location in patent: Page/Page column 26-28 ;
反应条件
acetic acid in ethyl acetate T=35 - 45°C; 0.333333 h;
参考文献
E. I. DU PONT DE NEMOURS AND COMPANY
Patent: WO2009/6061 A2, 2009 ;
Location in patent: Page/Page column 28 ;
反应条件
1: With hydrogenchloride in N,N-dimethyl-formamide T=10 - 30°C; 2: With sodium sulfite in water; N,N-dimethyl-formamide T=30 - 35°C; 3.25 h; 3: With sodium hydroxide; sodium sulfite in water; N,N-dimethyl-formamide T=10°C; pH=2.2; 0.25 h; Product distribution / selectivity;
参考文献
E.I. DUPONT DE NEMOURS AND COMPANY
Patent: WO2006/62978 A1, 2006 ;
Location in patent: Page/Page column 24 ;
反应条件
water; acetic acid in ethyl acetate T=48 - 52°C; 1 h; Product distribution / selectivity;
参考文献
WO2008/10897 A2, ;
Page/Page column 16 ;
反应条件
1: 2-amino-5-chloro-3-methyl-benzoic acid With thionyl chloride 3 h; Reflux; 2: methylamine in tetrahydrofuran; water T=20°C; Cooling with ice;
参考文献
Zhao, Yu; Xiong, Li-Xia; Xu, Li-Ping; Wang, Hongxue; Xu, Han; Li, Hua-Bin; Tong, Jun; Li, Zheng-Ming
Research on Chemical Intermediates, 2013 , vol. 39, # 7 p. 3071 - 3088
反应条件
in ethylene glycol; acetonitrile T=0 - 70°C; 17.5 - 23 h; Product distribution / selectivity;
参考文献
E.I. DUPONT DE NEMOURS AND COMPANY
Patent: WO2006/62978 A1, 2006 ;
Location in patent: Page/Page column 22-23; 23-24 ;
反应条件
1: thionyl chloride / Reflux 2: dichloromethane View Scheme
参考文献
Journal of Agricultural and Food Chemistry, , vol. 58, # 23 p. 12327 - 12336
Journal of Agricultural and Food Chemistry, , vol. 60, # 31 p. 7565 - 7572
反应条件
T=110°C; P=3876.26 Torr; 6.06667 h; Sealed tubeInert atmosphere; Product distribution / selectivity;
参考文献
WO2012/103436 A1, ;
Page/Page column 29-30 ;
反应条件
1.1: N-chloro-succinimide / N,N-dimethyl-formamide / 0.67 h / 100 °C 2.1: thionyl chloride / 3 h / |Reflux 2.2: 20 °C / |Cooling with ice View Scheme
参考文献
Chinese Journal of Chemistry, , vol. 30, # 8 p. 1748 - 1758
反应条件
1.1: sodium sulfate / water / 40 °C 1.2: |Reflux 2.1: sulfuric acid / 0.33 h / 80 °C 3.1: dihydrogen peroxide; sodium hydroxide / water / 0 - 50 °C 4.1: N-chloro-succinimide / N,N-dimethyl-formamide / 0.67 h / 100 °C 5.1: thionyl chloride / 3 h / |Reflux 5.2: 20 °C / |Cooling with ice View Scheme
参考文献
Chinese Journal of Chemistry, , vol. 30, # 8 p. 1748 - 1758
