1-(2-丙炔氧基)-2-(三氟甲基)苯合成路线 （共 4 条）
反应条件
1: N-chloro-succinimide; silver(I) acetate / acetone / 4 h / Reflux 2: sulfuric acid / 0.5 h / 20 °C View Scheme
参考文献
PHENEX PHARMACEUTICALS AG; STEENECK, Christoph; KINZEL, Olaf; GEGE, Christian; KLEYMANN, Gerald; HOFFMANN, Thomas
Patent: WO2012/139775 A1, 2012 ;
WO 2012/139775 A1
反应条件
potassium carbonate in acetonitrile
T=20°C;
参考文献
PHENEX PHARMACEUTICALS AG; STEENECK, Christoph; KINZEL, Olaf; GEGE, Christian; KLEYMANN, Gerald; HOFFMANN, Thomas
Patent: WO2012/139775 A1, 2012 ;
Location in patent: Page/Page column 59 ;
WO 2012/139775 A1
反应条件
potassium carbonate in acetonitrile
T=20°C; 96 h;
参考文献
Schmidt, Robert G.; Bayburt, Erol K.; Latshaw, Steven P.; Koenig, John R.; Daanen, Jerome F.; McDonald, Heath A.; Bianchi, Bruce R.; Zhong, Chengmin; Joshi, Shailen; Honore, Prisca; Marsh, Kennan C.; Lee, Chih-Hung; Faltynek, Connie R.; Gomtsyan, Arthur
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 5 p. 1338 - 1341
反应条件
N-chloro-succinimide; silver(I) acetate in acetone
6 h; Reflux;
参考文献
PHENEX PHARMACEUTICALS AG; STEENECK, Christoph; KINZEL, Olaf; GEGE, Christian; KLEYMANN, Gerald; HOFFMANN, Thomas
Patent: WO2012/139775 A1, 2012 ;
Location in patent: Page/Page column 59 ;
WO 2012/139775 A1
