8-(三氟甲基)苯并二氢吡喃-4-酮合成路线 （共 3 条）
反应条件
sulfuric acid in trifluoroacetic acid T=20°C; 72 h;
参考文献
ABBVIE INC.; Woller, Kevin R.; Gfesser, Gregory A.; Liu, Huaqing; Daanen, Jerome F.; Voight, Eric A.; Drizin, Irene I.; Shrestha, Anurupa; Mortell, Kathleen H.; Kym, Philip R.; Kort, Michael E.; Gomtsyan, Arthur
Patent: US2013/158067 A1, 2013 ;
Location in patent: Paragraph 0378 ;
反应条件
1: N-chloro-succinimide; silver(I) acetate / acetone / 4 h / Reflux 2: sulfuric acid / 0.5 h / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 5 p. 1338 - 1341
反应条件
1: potassium carbonate / acetonitrile / 96 h / 20 °C 2: N-chloro-succinimide; silver(I) acetate / acetone / 4 h / Reflux 3: sulfuric acid / 0.5 h / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 5 p. 1338 - 1341
