1-N-Boc-4-(3-cbz-氨基-3-甲氧基羰基烯丙基)-哌啶合成路线 （共 3 条）
反应条件
1: methyl ([(benzyloxy)carbonyl]amino)-(dimethoxyphosphoryl)acetate With N,N,N',N'-tetramethylguanidine in tetrahydrofuran T=-78°C; 0.166667 h; 2: 4-(2-oxo-ethyl)-piperidine-1-carboxylic acid tert-butyl ester in tetrahydrofuran T=0 - 20°C; 2 h;
参考文献
WO2008/97673 A1, ;
Page/Page column 24-25 ;
WO 2008/097673 A1
反应条件
hydrogen; (R,R)-ethyl-DuPHOS-Rh(COD) triflate in methanol T=20°C; P=3102.97 Torr; 24 h;
参考文献
IRM LLC
Patent: WO2008/97676 A1, 2008 ;
Location in patent: Page/Page column 26-27 ;
WO 2008/097676 A1
反应条件
1: methyl ([(benzyloxy)carbonyl]amino)-(dimethoxyphosphoryl)acetate With N,N,N',N'-tetramethylguanidine in tetrahydrofuran
T=-78°C; 0.166667 h;
2: 4-(2-oxo-ethyl)-piperidine-1-carboxylic acid tert-butyl ester in tetrahydrofuran
T=0 - 20°C; 2 h;
参考文献
IRM LLC
Patent: WO2008/97673 A1, 2008 ;
Location in patent: Page/Page column 24-25 ;
WO 2008/097673 A1
