1: With n-butyllithium in tetrahydrofuran T=-78°C; 1.5 h; 2: With bromocyane in tetrahydrofuran

1.1: toluene-4-sulfonic acid / toluene / 4 h / Reflux 2.1: n-butyllithium / tetrahydrofuran; hexanes / 1.5 h / -78 °C / Inert atmosphere 2.2: -78 - 20 °C View Scheme

potassium hydroxide; hydroxylamine hydrochloride in ethanol; water 60 h; Heating;