4-二对甲氧基苯胺基苯甲醛合成路线 （共 12 条）
反应条件
trichlorophosphate Vilsmeier-Haack reaction;
参考文献
Spraul, Bryan K.; Suresh; Sassa, Takafumi; Angeles Herranz; Echegoyen, Luis; Wada, Tatsuo; Perahia, Dvora; Smith Jr., Dennis W.
Tetrahedron Letters, 2004 , vol. 45, # 16 p. 3253 - 3256
反应条件
tris-(dibenzylideneacetone)dipalladium(0); tri-tert-butyl phosphine; sodium t-butanolate in toluene T=130°C; 18 h; Inert atmosphere;
参考文献
Davies, Joshua A.; Elangovan, Arumugasamy; Sullivan, Philip A.; Olbricht, Benjamin C.; Bale, Denise H.; Ewy, Todd R.; Isborn, Christine M.; Eichinger, Bruce E.; Robinson, Bruce H.; Reid, Philip J.; Li, Xiaosong; Dalton, Larry R.
Journal of the American Chemical Society, 2008 , vol. 130, # 32 p. 10565 - 10575
反应条件
1: Pd2dba3; dppf; t-BuONa / toluene / 110 °C 2: 79 percent / POCl3 / 90 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 127, # 48 p. 16900 - 16911
反应条件
1: Pd2dba3; dppf; t-BuONa / toluene / 110 °C 2: 79 percent / POCl3 / 90 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 127, # 48 p. 16900 - 16911
反应条件
diisobutylaluminium hydride in diethyl ether; toluene T=-50 - -20°C;
参考文献
Journal of Organic Chemistry, , vol. 68, # 3 p. 839 - 853
反应条件
1: 1.) Na, 2.) sym-collidine, CuI / 2.) reflux, 14 h 2: 1.) t-BuLi / 1.) THF, from -70 deg C to 65 deg C, 45 min, 2.) THF, from -65 deg C to RT, 12 h View Scheme
参考文献
Journal of the American Chemical Society, , vol. 121, # 6 p. 1324 - 1336
反应条件
1.1: 1,10-phenanthroline; copper(l) chloride; potassium hydroxide / anhydrous xylene / 72 h / 140 °C / Inert atmosphere 2.1: trichlorophosphate / 48 h / 0 - 120 °C / Inert atmosphere 2.2: 20 °C / Inert atmosphere; Cooling with ice View Scheme
参考文献
Dyes and Pigments, , vol. 88, # 3 p. 333 - 343
反应条件
1.1: 1,10-phenanthroline; copper(l) chloride; potassium hydroxide / anhydrous xylene / 72 h / 140 °C / Inert atmosphere 2.1: trichlorophosphate / 48 h / 0 - 120 °C / Inert atmosphere 2.2: 20 °C / Inert atmosphere; Cooling with ice View Scheme
参考文献
Dyes and Pigments, , vol. 88, # 3 p. 333 - 343
反应条件
tert.-butyl lithium 1.) THF, from -70 deg C to 65 deg C, 45 min, 2.) THF, from -65 deg C to RT, 12 h; Yield givenMultistep reaction;
参考文献
Journal of the American Chemical Society, , vol. 121, # 6 p. 1324 - 1336
反应条件
1: 64 percent / tris(dibenzylideneacetone)dipalladium(0); 1,1'-bis(diphenylphosphino)ferrocene; sodium tert-butoxide / toluene / 24 h / 106 - 110 °C 2: 69 percent / tris(dibenzylideneacetone)dipalladium(0); 1,1'-bis(diphenylphosphino)ferrocene; sodium tert-butoxide / toluene / 44 h / 111 °C 3: diisobutylaluminium hydride / diethyl ether; toluene / -50 - -20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 68, # 3 p. 839 - 853
