(2S)-2-甲基-2-哌啶羧酸合成路线 （共 13 条）
反应条件
hydrogen; palladium on activated charcoal in ethanol; acetic acid
1 h;
参考文献
Berrien, J. -F.; Royer, J.; Husson, H. -P.
Journal of Organic Chemistry, 1994 , vol. 59, # 14 p. 3769 - 3774
反应条件
trimethylsilyl iodide in chloroform
T=60°C;
参考文献
Matsumura, Yoshihiro; Kinoshita, Toshio; Yanagihara, Yuka; Kanemoto, Noriko; Watanabe, Mitsuaki
Tetrahedron Letters, 1996 , vol. 37, # 46 p. 8395 - 8398
反应条件
hydrogenchloride; Dowex 50-WX8; acetic acid in water; toluene
T=108°C; 160 h;
参考文献
Seebach, Dieter; Dziadulewicz, Edward; Behrendt, Linda; Cantoreggi, Sergio; Fitzi, Robert
Liebigs Annalen der Chemie, 1989 , p. 1215 - 1232
反应条件
1: 79 percent / LDA / -78 °C / 1.) THF, 30 min, 2.) HMPA, 3 h
2: 60 percent / H2 / 10percent Pd/C / ethanol; acetic acid / 1 h
View Scheme
参考文献
Berrien, J. -F.; Royer, J.; Husson, H. -P.
Journal of Organic Chemistry, 1994 , vol. 59, # 14 p. 3769 - 3774
反应条件
1.1: trifluoroacetic acid / 1,2-dichloro-ethane / 24 h / 20 °C / 2
1.2: 65 percent / diisopropylethylamine / tetrahydrofuran / 6 h / Heating
2.1: 81 percent / potassium bis(trimethylsilyl)amide; HMPA / tetrahydrofuran / 2 h / -78 - -70 °C
3.1: H2 / Pd(OH)2/C / methanol; H2O / 24 h / 20 °C / 3750.3 Torr
View Scheme
参考文献
Hou, Duen-Ren; Hung, Shin-Yi; Hu, Chung-Cheng
Tetrahedron Asymmetry, 2005 , vol. 16, # 23 p. 3858 - 3864
反应条件
1: 81 percent / potassium bis(trimethylsilyl)amide; HMPA / tetrahydrofuran / 2 h / -78 - -70 °C
2: H2 / Pd(OH)2/C / methanol; H2O / 24 h / 20 °C / 3750.3 Torr
View Scheme
参考文献
Hou, Duen-Ren; Hung, Shin-Yi; Hu, Chung-Cheng
Tetrahedron Asymmetry, 2005 , vol. 16, # 23 p. 3858 - 3864
反应条件
1: 1) CH3CN, 45 deg C, ultrasound, 48h, 2) CH3CN, 2h
2: 82 percent / 30percent H2O2, 10percent Na2CO3 / acetone / 18 h / 45 °C / ultrasound
3: 68 percent / H2 / 10percent Pd-C / methanol / 48 h / 760 Torr
4: 56 percent / conc. HCl / 18 h / Heating
View Scheme
参考文献
Shatzmiller, Shimon; Dolithzky, Ben-Zion; Bahar, Eliezer
Liebigs Annalen der Chemie, 1991 , # 4 p. 375 - 379
反应条件
1: 82 percent / 30percent H2O2, 10percent Na2CO3 / acetone / 18 h / 45 °C / ultrasound
2: 68 percent / H2 / 10percent Pd-C / methanol / 48 h / 760 Torr
3: 56 percent / conc. HCl / 18 h / Heating
View Scheme
参考文献
Shatzmiller, Shimon; Dolithzky, Ben-Zion; Bahar, Eliezer
Liebigs Annalen der Chemie, 1991 , # 4 p. 375 - 379
反应条件
1: 68 percent / H2 / 10percent Pd-C / methanol / 48 h / 760 Torr
2: 56 percent / conc. HCl / 18 h / Heating
View Scheme
参考文献
Shatzmiller, Shimon; Dolithzky, Ben-Zion; Bahar, Eliezer
Liebigs Annalen der Chemie, 1991 , # 4 p. 375 - 379
反应条件
hydrogenchloride
18 h; Heating;
参考文献
Shatzmiller, Shimon; Dolithzky, Ben-Zion; Bahar, Eliezer
Liebigs Annalen der Chemie, 1991 , # 4 p. 375 - 379
