(2S)-2-甲基-2-哌啶羧酸合成路线 （共 13 条）
反应条件
1: 90 percent / Bu3SnH / benzene / 1 h / 85 °C
2: 50 percent / Me3SiI / CHCl3 / 60 °C
View Scheme
参考文献
Matsumura, Yoshihiro; Kinoshita, Toshio; Yanagihara, Yuka; Kanemoto, Noriko; Watanabe, Mitsuaki
Tetrahedron Letters, 1996 , vol. 37, # 46 p. 8395 - 8398
反应条件
1: 86 percent / anhydrous Na2CO3, anhydrous NaI / acetonitrile / 4.5 h / Heating
2: 58 percent / 0.75M HCl, Dowex 50-WX8, acetic acid / H2O; toluene / 160 h / 108 °C
View Scheme
参考文献
Seebach, Dieter; Dziadulewicz, Edward; Behrendt, Linda; Cantoreggi, Sergio; Fitzi, Robert
Liebigs Annalen der Chemie, 1989 , p. 1215 - 1232
反应条件
1: 73 percent / trifluoroacetic acid / CH2Cl2 / 2 h / 35 - 40 °C
2: 86 percent / anhydrous Na2CO3, anhydrous NaI / acetonitrile / 4.5 h / Heating
3: 58 percent / 0.75M HCl, Dowex 50-WX8, acetic acid / H2O; toluene / 160 h / 108 °C
View Scheme
参考文献
Seebach, Dieter; Dziadulewicz, Edward; Behrendt, Linda; Cantoreggi, Sergio; Fitzi, Robert
Liebigs Annalen der Chemie, 1989 , p. 1215 - 1232
