2,4-二羟基-7,8,9,10-四氢氮杂卓并[2,1-b]喹唑啉-12(6H)-酮合成路线 （共 6 条）
反应条件
hydrogen bromide
12 h; Inert atmosphereReflux;
参考文献
Nepali, Kunal; Bande, Mukunda S.; Sapra, Sameer; Garg, Atul; Kumar, Sunil; Sharma, Punita; Goyal, Rohit; Satti, Naresh Kumar; Suri, Om Parkash; Dhar, Kanaya Lal
Medicinal Chemistry Research, 2012 , vol. 21, # 7 p. 1271 - 1277
反应条件
1: 64.23 percent / CuCl2 / methanol / 14 h / 120 °C / 4240.61 Torr
2: 46.88 percent / HBr / H2O / 12 h / Heating
View Scheme
参考文献
Zabeer; Bhagat; Gupta; Singh; Youssouf; Dhar; Suri; Satti; Qazi
European Journal of Medicinal Chemistry, 2006 , vol. 41, # 3 p. 429 - 434
反应条件
1.1: 59.66 percent / Br2 / methanol / 3 h / 50 °C
2.1: SOCl2 / benzene / 2 h / Heating
2.2: 73.65 percent / benzene / 12 h
3.1: 64.23 percent / CuCl2 / methanol / 14 h / 120 °C / 4240.61 Torr
4.1: 46.88 percent / HBr / H2O / 12 h / Heating
View Scheme
参考文献
Zabeer; Bhagat; Gupta; Singh; Youssouf; Dhar; Suri; Satti; Qazi
European Journal of Medicinal Chemistry, 2006 , vol. 41, # 3 p. 429 - 434
反应条件
1.1: SOCl2 / benzene / 2 h / Heating
1.2: 73.65 percent / benzene / 12 h
2.1: 64.23 percent / CuCl2 / methanol / 14 h / 120 °C / 4240.61 Torr
3.1: 46.88 percent / HBr / H2O / 12 h / Heating
View Scheme
参考文献
Zabeer; Bhagat; Gupta; Singh; Youssouf; Dhar; Suri; Satti; Qazi
European Journal of Medicinal Chemistry, 2006 , vol. 41, # 3 p. 429 - 434
反应条件
1.1: thionyl chloride / benzene / 3 h / Reflux; Inert atmosphere
1.2: Cooling; Inert atmosphere
2.1: sodium tetrahydroborate / ethanol / 20 °C
3.1: bromine / tetrachloromethane / 20 °C
4.1: sodium methylate; copper dichloride / 12 h / Inert atmosphere; Reflux
5.1: hydrogen bromide / 12 h / Inert atmosphere; Reflux
View Scheme
参考文献
Nepali, Kunal; Bande, Mukunda S.; Sapra, Sameer; Garg, Atul; Kumar, Sunil; Sharma, Punita; Goyal, Rohit; Satti, Naresh Kumar; Suri, Om Parkash; Dhar, Kanaya Lal
Medicinal Chemistry Research, 2012 , vol. 21, # 7 p. 1271 - 1277
反应条件
1: bromine / tetrachloromethane / 20 °C
2: sodium methylate; copper dichloride / 12 h / Inert atmosphere; Reflux
3: hydrogen bromide / 12 h / Inert atmosphere; Reflux
View Scheme
参考文献
Nepali, Kunal; Bande, Mukunda S.; Sapra, Sameer; Garg, Atul; Kumar, Sunil; Sharma, Punita; Goyal, Rohit; Satti, Naresh Kumar; Suri, Om Parkash; Dhar, Kanaya Lal
Medicinal Chemistry Research, 2012 , vol. 21, # 7 p. 1271 - 1277
