N-Boc-4-哌啶乙醇合成路线 （共 41 条）
反应条件
1: triethylamine / dichloromethane / 16 h / 5 - 20 °C
2: 2-(tert-butyl)-1,1,3,3-tetramethylguanidine / N,N-dimethyl-formamide / 10 h / 80 °C
3: trifluoroacetic acid / dichloromethane / 2 h / 10 - 20 °C
4: triethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran; N,N-dimethyl-formamide / 10 h / 20 °C
View Scheme
参考文献
Kim, Se-Ho; Bajji, Ashok; Tangallapally, Rajendra; Markovitz, Benjamin; Trovato, Richard; Shenderovich, Mark; Baichwal, Vijay; Bartel, Paul; Cimbora, Daniel; McKinnon, Rena; Robinson, Rosann; Papac, Damon; Wettstein, Daniel; Carlson, Robert; Yager, Kraig M.
Journal of Medicinal Chemistry, 2012 , vol. 55, # 17 p. 7480 - 7501
